Intrauterine Growth Restricted Rats Exercised before and during Pregnancy: Maternal and Perinatal Repercussions
This study aimed at evaluating the effect of swimming before and during pregnancy on rats born with intrauterine growth restriction (IUGR) and their offspring. For this, nondiabetic and streptozotocin-induced severely diabetic (SD) pregnant rats were mated and generated offspring with appropriate (c...
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Online Access: | http://dx.doi.org/10.1155/2015/294850 |
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doaj-b903029cef55448a9bf416f32cab6b282020-11-24T22:36:06ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882015-01-01201510.1155/2015/294850294850Intrauterine Growth Restricted Rats Exercised before and during Pregnancy: Maternal and Perinatal RepercussionsS. B. Corvino0G. T. Volpato1M. V. C. Rudge2D. C. Damasceno3Laboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Obstetrics and Mastology Graduate Course, Botucatu Medical School, São Paulo State University (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Obstetrics and Mastology Graduate Course, Botucatu Medical School, São Paulo State University (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Obstetrics and Mastology Graduate Course, Botucatu Medical School, São Paulo State University (Unesp), 18618-970 Botucatu, SP, BrazilLaboratory of Experimental Research on Gynecology and Obstetrics, Gynecology, Obstetrics and Mastology Graduate Course, Botucatu Medical School, São Paulo State University (Unesp), 18618-970 Botucatu, SP, BrazilThis study aimed at evaluating the effect of swimming before and during pregnancy on rats born with intrauterine growth restriction (IUGR) and their offspring. For this, nondiabetic and streptozotocin-induced severely diabetic (SD) pregnant rats were mated and generated offspring with appropriate (control, C) and small (IUGR) for pregnancy age, respectively. Following that, C and IUGR groups were further distributed into nonexercised control (C), exercised control (Cex), nonexercised IUGR (IUGR), and exercised IUGR (IUGRex). IUGR rats presented lower mating rate than control rats. Regardless of physical exercise IUGR rats presented decreased body weight from birth to lactation. At 90 days of life, IUGR rats presented glucose intolerance. Maternal organ weights were increased and relative adiposity of IUGRex rats was lower than Cex. IUGR and IUGRex offspring presented reduced body weight than C and Cex, respectively. IUGRex dams presented an increased rate of appropriate for pregnancy age newborns. IUGEex male and female offspring relative brain weight was increased compared with Cex. Therefore, swimming before and during pregnancy prevented glucose intolerance, reduced general adiposity, and increased maternal and offspring organ weight in rats, showing the benefit of physical exercise for IUGR rats.http://dx.doi.org/10.1155/2015/294850 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
S. B. Corvino G. T. Volpato M. V. C. Rudge D. C. Damasceno |
spellingShingle |
S. B. Corvino G. T. Volpato M. V. C. Rudge D. C. Damasceno Intrauterine Growth Restricted Rats Exercised before and during Pregnancy: Maternal and Perinatal Repercussions Evidence-Based Complementary and Alternative Medicine |
author_facet |
S. B. Corvino G. T. Volpato M. V. C. Rudge D. C. Damasceno |
author_sort |
S. B. Corvino |
title |
Intrauterine Growth Restricted Rats Exercised before and during Pregnancy: Maternal and Perinatal Repercussions |
title_short |
Intrauterine Growth Restricted Rats Exercised before and during Pregnancy: Maternal and Perinatal Repercussions |
title_full |
Intrauterine Growth Restricted Rats Exercised before and during Pregnancy: Maternal and Perinatal Repercussions |
title_fullStr |
Intrauterine Growth Restricted Rats Exercised before and during Pregnancy: Maternal and Perinatal Repercussions |
title_full_unstemmed |
Intrauterine Growth Restricted Rats Exercised before and during Pregnancy: Maternal and Perinatal Repercussions |
title_sort |
intrauterine growth restricted rats exercised before and during pregnancy: maternal and perinatal repercussions |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2015-01-01 |
description |
This study aimed at evaluating the effect of swimming before and during pregnancy on rats born with intrauterine growth restriction (IUGR) and their offspring. For this, nondiabetic and streptozotocin-induced severely diabetic (SD) pregnant rats were mated and generated offspring with appropriate (control, C) and small (IUGR) for pregnancy age, respectively. Following that, C and IUGR groups were further distributed into nonexercised control (C), exercised control (Cex), nonexercised IUGR (IUGR), and exercised IUGR (IUGRex). IUGR rats presented lower mating rate than control rats. Regardless of physical exercise IUGR rats presented decreased body weight from birth to lactation. At 90 days of life, IUGR rats presented glucose intolerance. Maternal organ weights were increased and relative adiposity of IUGRex rats was lower than Cex. IUGR and IUGRex offspring presented reduced body weight than C and Cex, respectively. IUGRex dams presented an increased rate of appropriate for pregnancy age newborns. IUGEex male and female offspring relative brain weight was increased compared with Cex. Therefore, swimming before and during pregnancy prevented glucose intolerance, reduced general adiposity, and increased maternal and offspring organ weight in rats, showing the benefit of physical exercise for IUGR rats. |
url |
http://dx.doi.org/10.1155/2015/294850 |
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