Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women.
BACKGROUND:More than two-fifths of the world's population uses solid fuels, mostly biomass, for cooking. The resulting biomass smoke exposure is a major cause of chronic obstructive pulmonary disease (COPD) among women in developing countries. OBJECTIVE:To assess whether lower woodsmoke exposur...
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doaj-b907efcf99114c018ad80916f3551f892020-11-25T01:18:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0193e8845510.1371/journal.pone.0088455Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women.Michael J GuarnieriJanet V DiazChandreyi BasuAnaite DiazDaniel PopeKirk R SmithTone Smith-SivertsenNigel BruceColin SolomonJohn McCrackenJohn R BalmesBACKGROUND:More than two-fifths of the world's population uses solid fuels, mostly biomass, for cooking. The resulting biomass smoke exposure is a major cause of chronic obstructive pulmonary disease (COPD) among women in developing countries. OBJECTIVE:To assess whether lower woodsmoke exposure from use of a stove with a chimney, compared to open fires, is associated with lower markers of airway inflammation in young women. DESIGN:We carried out a cross-sectional analysis on a sub-cohort of participants enrolled in a randomized controlled trial in rural Guatemala, RESPIRE. PARTICIPANTS:We recruited 45 indigenous women at the end of the 18-month trial; 19 women who had been using the chimney stove for 18-24 months and 26 women still using open fires. MEASUREMENTS:We obtained spirometry and induced sputum for cell counts, gene expression of IL-8, TNF-α, MMP-9 and 12, and protein concentrations of IL-8, myeloperoxidase and fibronectin. Exhaled carbon monoxide (CO) and 48-hr personal CO tubes were measured to assess smoke exposure. RESULTS:MMP-9 gene expression was significantly lower in women using chimney stoves. Higher exhaled CO concentrations were significantly associated with higher gene expression of IL-8, TNF-α, and MMP-9. Higher 48-hr personal CO concentrations were associated with higher gene expression of IL-8, TNF- α, MMP-9 and MMP-12; reaching statistical significance for MMP-9 and MMP-12. CONCLUSIONS:Compared to using an open wood fire for cooking, use of a chimney stove was associated with lower gene expression of MMP-9, a potential mediator of airway remodeling. Among all participants, indoor biomass smoke exposure was associated with higher gene expression of multiple mediators of airway inflammation and remodeling; these mechanisms may explain some of the observed association between prolonged biomass smoke exposure and COPD.http://europepmc.org/articles/PMC3953023?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michael J Guarnieri Janet V Diaz Chandreyi Basu Anaite Diaz Daniel Pope Kirk R Smith Tone Smith-Sivertsen Nigel Bruce Colin Solomon John McCracken John R Balmes |
spellingShingle |
Michael J Guarnieri Janet V Diaz Chandreyi Basu Anaite Diaz Daniel Pope Kirk R Smith Tone Smith-Sivertsen Nigel Bruce Colin Solomon John McCracken John R Balmes Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women. PLoS ONE |
author_facet |
Michael J Guarnieri Janet V Diaz Chandreyi Basu Anaite Diaz Daniel Pope Kirk R Smith Tone Smith-Sivertsen Nigel Bruce Colin Solomon John McCracken John R Balmes |
author_sort |
Michael J Guarnieri |
title |
Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women. |
title_short |
Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women. |
title_full |
Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women. |
title_fullStr |
Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women. |
title_full_unstemmed |
Effects of woodsmoke exposure on airway inflammation in rural Guatemalan women. |
title_sort |
effects of woodsmoke exposure on airway inflammation in rural guatemalan women. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
BACKGROUND:More than two-fifths of the world's population uses solid fuels, mostly biomass, for cooking. The resulting biomass smoke exposure is a major cause of chronic obstructive pulmonary disease (COPD) among women in developing countries. OBJECTIVE:To assess whether lower woodsmoke exposure from use of a stove with a chimney, compared to open fires, is associated with lower markers of airway inflammation in young women. DESIGN:We carried out a cross-sectional analysis on a sub-cohort of participants enrolled in a randomized controlled trial in rural Guatemala, RESPIRE. PARTICIPANTS:We recruited 45 indigenous women at the end of the 18-month trial; 19 women who had been using the chimney stove for 18-24 months and 26 women still using open fires. MEASUREMENTS:We obtained spirometry and induced sputum for cell counts, gene expression of IL-8, TNF-α, MMP-9 and 12, and protein concentrations of IL-8, myeloperoxidase and fibronectin. Exhaled carbon monoxide (CO) and 48-hr personal CO tubes were measured to assess smoke exposure. RESULTS:MMP-9 gene expression was significantly lower in women using chimney stoves. Higher exhaled CO concentrations were significantly associated with higher gene expression of IL-8, TNF-α, and MMP-9. Higher 48-hr personal CO concentrations were associated with higher gene expression of IL-8, TNF- α, MMP-9 and MMP-12; reaching statistical significance for MMP-9 and MMP-12. CONCLUSIONS:Compared to using an open wood fire for cooking, use of a chimney stove was associated with lower gene expression of MMP-9, a potential mediator of airway remodeling. Among all participants, indoor biomass smoke exposure was associated with higher gene expression of multiple mediators of airway inflammation and remodeling; these mechanisms may explain some of the observed association between prolonged biomass smoke exposure and COPD. |
url |
http://europepmc.org/articles/PMC3953023?pdf=render |
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