ANTIHYPERTENSIVE DRUG THERAPY FOR HYPERTENSIVE DISORDERS IN PREGNANCY
Hypertension in pregnancy is associated with increased maternal and fetal mortality and morbidity. About 8 % of all pregnancies are complicated with hypertensive disorders. There is concordance that severe hypertension should be treated without delay to reduce maternal risks of acute cerebrovascula...
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University in Nis, Faculty of Medicine
2008-10-01
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doaj-b91d60ec5b534aaa9ec7e484b839fe902020-11-24T22:24:19ZengUniversity in Nis, Faculty of MedicineActa Medica Medianae0365-44782008-10-014736572ANTIHYPERTENSIVE DRUG THERAPY FOR HYPERTENSIVE DISORDERS IN PREGNANCYSlobodan JankovicMihajlo JakovljevicMirjana VarjacicNevena FolicMarko FolicHypertension in pregnancy is associated with increased maternal and fetal mortality and morbidity. About 8 % of all pregnancies are complicated with hypertensive disorders. There is concordance that severe hypertension should be treated without delay to reduce maternal risks of acute cerebrovascular complications. Intravenous labetalol and oral nifedipine are as effective as intravenous hydralazine in control of severe hypertension, with less adverse effects. Still, there is no consensus as to whether mild-to-moderate hypertension in pregnancy should be treated, considering that there are no definitive conclusions which can be made about the relative maternal or perinatal benefits/risks of antihypertensive treatment. Considering their safe usage during pregnancy, methyldopa, labetalol and nifedipine are commonly used blood-pressure lowering drugs for pregnant women with hypertension. The cardio-selective β- blocker atenolol should be avoided in pregnancy, because it has been associated with lower birth weights and fetal growth impairment. ACE inhibitors and angiotensin receptor blockers are contraindicated in pregnancy. http://publisher.medfak.ni.ac.rs/2008-html/3-broj/ANTIHYPERTENSIVE%20DRUG%20THERAPY....pdfantihypertensive drugshypertensive disorderspregnancy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Slobodan Jankovic Mihajlo Jakovljevic Mirjana Varjacic Nevena Folic Marko Folic |
spellingShingle |
Slobodan Jankovic Mihajlo Jakovljevic Mirjana Varjacic Nevena Folic Marko Folic ANTIHYPERTENSIVE DRUG THERAPY FOR HYPERTENSIVE DISORDERS IN PREGNANCY Acta Medica Medianae antihypertensive drugs hypertensive disorders pregnancy |
author_facet |
Slobodan Jankovic Mihajlo Jakovljevic Mirjana Varjacic Nevena Folic Marko Folic |
author_sort |
Slobodan Jankovic |
title |
ANTIHYPERTENSIVE DRUG THERAPY FOR HYPERTENSIVE DISORDERS IN PREGNANCY |
title_short |
ANTIHYPERTENSIVE DRUG THERAPY FOR HYPERTENSIVE DISORDERS IN PREGNANCY |
title_full |
ANTIHYPERTENSIVE DRUG THERAPY FOR HYPERTENSIVE DISORDERS IN PREGNANCY |
title_fullStr |
ANTIHYPERTENSIVE DRUG THERAPY FOR HYPERTENSIVE DISORDERS IN PREGNANCY |
title_full_unstemmed |
ANTIHYPERTENSIVE DRUG THERAPY FOR HYPERTENSIVE DISORDERS IN PREGNANCY |
title_sort |
antihypertensive drug therapy for hypertensive disorders in pregnancy |
publisher |
University in Nis, Faculty of Medicine |
series |
Acta Medica Medianae |
issn |
0365-4478 |
publishDate |
2008-10-01 |
description |
Hypertension in pregnancy is associated with increased maternal and fetal mortality and morbidity. About 8 % of all pregnancies are complicated with hypertensive disorders. There is concordance that severe hypertension should be treated without delay to reduce maternal risks of acute cerebrovascular complications. Intravenous labetalol and oral nifedipine are as effective as intravenous hydralazine in control of severe hypertension, with less adverse effects. Still, there is no consensus as to whether mild-to-moderate hypertension in pregnancy should be treated, considering that there are no definitive conclusions which can be made about the relative maternal or perinatal benefits/risks of antihypertensive treatment. Considering their safe usage during pregnancy, methyldopa, labetalol and nifedipine are commonly used blood-pressure lowering drugs for pregnant women with hypertension. The cardio-selective β- blocker atenolol should be avoided in pregnancy, because it has been associated with lower birth weights and fetal growth impairment. ACE inhibitors and angiotensin receptor blockers are contraindicated in pregnancy. |
topic |
antihypertensive drugs hypertensive disorders pregnancy |
url |
http://publisher.medfak.ni.ac.rs/2008-html/3-broj/ANTIHYPERTENSIVE%20DRUG%20THERAPY....pdf |
work_keys_str_mv |
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