A Comprehensive Meta-analysis on Intra Ocular Pressure and Central Corneal Thickness in Healthy Children
Background: Glaucoma is the major ophthalmic public health issue and a leading basis of blindness. Elevated intraocular pressure (IOP) is still a foremost risk factor in development and progression of glaucoma. Central corneal thickness (CCT) may play as the risk factor for the progression of glauc...
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Tehran University of Medical Sciences
2017-05-01
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doaj-b92283e3a0ec4838b7a53e8d471e75e72021-01-02T15:40:24ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932017-05-01466A Comprehensive Meta-analysis on Intra Ocular Pressure and Central Corneal Thickness in Healthy ChildrenMajid FARVARDIN0Fatemeh HEIDARY1Kourosh SAYEHMIRI2Reza GHAREBAGHI3Mahmoud JABBARVAND BEHROOZ4Poostchi Eye Research Center, Dept. of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, IranPoostchi Eye Research Center, Dept. of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, Iran AND Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, IranDept. of Biostatistics and Epidemiology, Ilam University of Medical Sciences, Ilam, IranPoostchi Eye Research Center, Dept. of Ophthalmology, Shiraz University of Medical Sciences, Shiraz, IranEye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran Background: Glaucoma is the major ophthalmic public health issue and a leading basis of blindness. Elevated intraocular pressure (IOP) is still a foremost risk factor in development and progression of glaucoma. Central corneal thickness (CCT) may play as the risk factor for the progression of glaucoma, closely associated with IOP especially in pediatric age group. This study performed a pioneering investigation combining the outcomes of multiple studies using a meta-analytic approach. Methods: Nineteen published articles between 1980 and 2015 were designated by searching Scopus, PubMed, and Google Scholar and analyzed with random effects model while I² statistics employed to find out heterogeneity. Subsequently, the information statistically analyzed by Stata software ver. 11.20. Results: The mean IOP has been documented to 16.22 mmHg (95% CI: 15.48-16.97) in all races subgroups. Analyzing the data by race-based subgroups revealed the lowest IOP of 12.02 mmHg (95% CI: 11.40-12.64) in Indian children while IOP of 17.38 mmHg (95% CI: 15.77-18.98) documented in black children as the highest measurement. The mean CCT was 553.69 micrometer (95% CI: 551.60-555.78) among all races. Lowest CCT of 536.60 mm (95% CI: 531.82-541.38) has been documented in mixed Malay-Indian children whereas Chinese children ought to the highest CCT value of 557.68 mm (95% CI: 553.10-562.25). Conclusion: Findings of published studies were inconsistent when considered independently; however, meta-analysis of these results showed a significant correlation between CCT and IOP. Owing to non-uniform methods used to measure IOP and CCT in studies, data were stratified into various subgroups according to the instruments used to measure IOP and CCT. https://ijph.tums.ac.ir/index.php/ijph/article/view/10074Central corneal thicknessIntraocular pressureChildrenCorrelationMeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Majid FARVARDIN Fatemeh HEIDARY Kourosh SAYEHMIRI Reza GHAREBAGHI Mahmoud JABBARVAND BEHROOZ |
spellingShingle |
Majid FARVARDIN Fatemeh HEIDARY Kourosh SAYEHMIRI Reza GHAREBAGHI Mahmoud JABBARVAND BEHROOZ A Comprehensive Meta-analysis on Intra Ocular Pressure and Central Corneal Thickness in Healthy Children Iranian Journal of Public Health Central corneal thickness Intraocular pressure Children Correlation Meta-analysis |
author_facet |
Majid FARVARDIN Fatemeh HEIDARY Kourosh SAYEHMIRI Reza GHAREBAGHI Mahmoud JABBARVAND BEHROOZ |
author_sort |
Majid FARVARDIN |
title |
A Comprehensive Meta-analysis on Intra Ocular Pressure and Central Corneal Thickness in Healthy Children |
title_short |
A Comprehensive Meta-analysis on Intra Ocular Pressure and Central Corneal Thickness in Healthy Children |
title_full |
A Comprehensive Meta-analysis on Intra Ocular Pressure and Central Corneal Thickness in Healthy Children |
title_fullStr |
A Comprehensive Meta-analysis on Intra Ocular Pressure and Central Corneal Thickness in Healthy Children |
title_full_unstemmed |
A Comprehensive Meta-analysis on Intra Ocular Pressure and Central Corneal Thickness in Healthy Children |
title_sort |
comprehensive meta-analysis on intra ocular pressure and central corneal thickness in healthy children |
publisher |
Tehran University of Medical Sciences |
series |
Iranian Journal of Public Health |
issn |
2251-6085 2251-6093 |
publishDate |
2017-05-01 |
description |
Background: Glaucoma is the major ophthalmic public health issue and a leading basis of blindness. Elevated intraocular pressure (IOP) is still a foremost risk factor in development and progression of glaucoma. Central corneal thickness (CCT) may play as the risk factor for the progression of glaucoma, closely associated with IOP especially in pediatric age group. This study performed a pioneering investigation combining the outcomes of multiple studies using a meta-analytic approach.
Methods: Nineteen published articles between 1980 and 2015 were designated by searching Scopus, PubMed, and Google Scholar and analyzed with random effects model while I² statistics employed to find out heterogeneity. Subsequently, the information statistically analyzed by Stata software ver. 11.20.
Results: The mean IOP has been documented to 16.22 mmHg (95% CI: 15.48-16.97) in all races subgroups. Analyzing the data by race-based subgroups revealed the lowest IOP of 12.02 mmHg (95% CI: 11.40-12.64) in Indian children while IOP of 17.38 mmHg (95% CI: 15.77-18.98) documented in black children as the highest measurement. The mean CCT was 553.69 micrometer (95% CI: 551.60-555.78) among all races. Lowest CCT of 536.60 mm (95% CI: 531.82-541.38) has been documented in mixed Malay-Indian children whereas Chinese children ought to the highest CCT value of 557.68 mm (95% CI: 553.10-562.25).
Conclusion: Findings of published studies were inconsistent when considered independently; however, meta-analysis of these results showed a significant correlation between CCT and IOP. Owing to non-uniform methods used to measure IOP and CCT in studies, data were stratified into various subgroups according to the instruments used to measure IOP and CCT.
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topic |
Central corneal thickness Intraocular pressure Children Correlation Meta-analysis |
url |
https://ijph.tums.ac.ir/index.php/ijph/article/view/10074 |
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