Direct-Acting Antiviral Treatment of HCV Infection Does Not Resolve the Dysfunction of Circulating CD8+ T-Cells in Advanced Liver Disease

Direct-Acting Antiviral Treatment of HCV Infection Does Not Resolve the Dysfunction of Circulating CD8+ T-Cells in Advanced Liver Disease

Chronic hepatitis C virus (HCV) infection disrupts immune functions, including that of cytotoxic CD8+ T-cells which are important mediators of immune response. While HCV cure aims to eliminate long term sequelae of infection, whether direct-acting antiviral (DAA) treatment results in immune reconsti...

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Bibliographic Details
Main Authors: Agatha Vranjkovic, Felicia Deonarine, Shaima Kaka, Jonathan B. Angel, Curtis L. Cooper, Angela M. Crawley
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
CD8+ T-cells
HCV
liver
direct-acting antivirals
fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01926/full

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