Crataegus pinnatifida: Chemical Constituents, Pharmacology, and Potential Applications
Crataegus pinnatifida (Hawthorn) is widely distributed in China and has a long history of use as a traditional medicine. The fruit of C. pinnatifida has been used for the treatment of cardiodynia, hernia, dyspepsia, postpartum blood stasis, and hemafecia and thus increasing interest in this plant ha...
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doaj-b92bbe66b4e2462895b91c7b8a742ac12020-11-25T00:28:43ZengMDPI AGMolecules1420-30492014-01-011921685171210.3390/molecules19021685molecules19021685Crataegus pinnatifida: Chemical Constituents, Pharmacology, and Potential ApplicationsJiaqi Wu0Wei Peng1Rongxin Qin2Hong Zhou3Department of Pharmacology, College of Pharmacy, The Third Military Medical University, Chongqing 400038, ChinaDepartment of Pharmacology, College of Pharmacy, The Third Military Medical University, Chongqing 400038, ChinaDepartment of Pharmacology, College of Pharmacy, The Third Military Medical University, Chongqing 400038, ChinaDepartment of Pharmacology, College of Pharmacy, The Third Military Medical University, Chongqing 400038, ChinaCrataegus pinnatifida (Hawthorn) is widely distributed in China and has a long history of use as a traditional medicine. The fruit of C. pinnatifida has been used for the treatment of cardiodynia, hernia, dyspepsia, postpartum blood stasis, and hemafecia and thus increasing interest in this plant has emerged in recent years. Between 1966 and 2013, numerous articles have been published on the chemical constituents, pharmacology or pharmacologic effects and toxicology of C. pinnatifida. To review the pharmacologic advances and to discuss the potential perspective for future investigation, we have summarized the main literature findings of these publications. So far, over 150 compounds including flavonoids, triterpenoids, steroids, monoterpenoids, sesquiterpenoids, lignans, hydroxycinnamic acids, organic acids and nitrogen-containing compounds have been isolated and identified from C. pinnatifida. It has been found that these constituents and extracts of C. pinnatifida have broad pharmacological effects with low toxicity on, for example, the cardiovascular, digestive, and endocrine systems, and pathogenic microorganisms, supporting the view that C. pinnatifida has favorable therapeutic effects. Thus, although C. pinnatifida has already been widely used as pharmacological therapy, due to its various active compounds, further research is warranted to develop new drugs.http://www.mdpi.com/1420-3049/19/2/1685Crataegus pinnatifidachemical compositionpharmacologytoxicology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiaqi Wu Wei Peng Rongxin Qin Hong Zhou |
spellingShingle |
Jiaqi Wu Wei Peng Rongxin Qin Hong Zhou Crataegus pinnatifida: Chemical Constituents, Pharmacology, and Potential Applications Molecules Crataegus pinnatifida chemical composition pharmacology toxicology |
author_facet |
Jiaqi Wu Wei Peng Rongxin Qin Hong Zhou |
author_sort |
Jiaqi Wu |
title |
Crataegus pinnatifida: Chemical Constituents, Pharmacology, and Potential Applications |
title_short |
Crataegus pinnatifida: Chemical Constituents, Pharmacology, and Potential Applications |
title_full |
Crataegus pinnatifida: Chemical Constituents, Pharmacology, and Potential Applications |
title_fullStr |
Crataegus pinnatifida: Chemical Constituents, Pharmacology, and Potential Applications |
title_full_unstemmed |
Crataegus pinnatifida: Chemical Constituents, Pharmacology, and Potential Applications |
title_sort |
crataegus pinnatifida: chemical constituents, pharmacology, and potential applications |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2014-01-01 |
description |
Crataegus pinnatifida (Hawthorn) is widely distributed in China and has a long history of use as a traditional medicine. The fruit of C. pinnatifida has been used for the treatment of cardiodynia, hernia, dyspepsia, postpartum blood stasis, and hemafecia and thus increasing interest in this plant has emerged in recent years. Between 1966 and 2013, numerous articles have been published on the chemical constituents, pharmacology or pharmacologic effects and toxicology of C. pinnatifida. To review the pharmacologic advances and to discuss the potential perspective for future investigation, we have summarized the main literature findings of these publications. So far, over 150 compounds including flavonoids, triterpenoids, steroids, monoterpenoids, sesquiterpenoids, lignans, hydroxycinnamic acids, organic acids and nitrogen-containing compounds have been isolated and identified from C. pinnatifida. It has been found that these constituents and extracts of C. pinnatifida have broad pharmacological effects with low toxicity on, for example, the cardiovascular, digestive, and endocrine systems, and pathogenic microorganisms, supporting the view that C. pinnatifida has favorable therapeutic effects. Thus, although C. pinnatifida has already been widely used as pharmacological therapy, due to its various active compounds, further research is warranted to develop new drugs. |
topic |
Crataegus pinnatifida chemical composition pharmacology toxicology |
url |
http://www.mdpi.com/1420-3049/19/2/1685 |
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