Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish

The adult zebrafish heart is capable of regeneration but the molecular mechanisms are poorly understood. Here the authors show that chromatin remodeling factor Brg1 represses cyclin-dependent kinase inhibitors to promote myocardial regeneration.

Bibliographic Details
Main Authors:	Chenglu Xiao, Lu Gao, Yu Hou, Congfei Xu, Nannan Chang, Fang Wang, Keping Hu, Aibin He, Ying Luo, Jun Wang, Jinrong Peng, Fuchou Tang, Xiaojun Zhu, Jing-Wei Xiong
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms13787

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spelling	doaj-b93453a1fef44a088b1bca315686928d2021-05-11T11:06:44ZengNature Publishing GroupNature Communications2041-17232016-12-017111310.1038/ncomms13787Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafishChenglu Xiao0Lu Gao1Yu Hou2Congfei Xu3Nannan Chang4Fang Wang5Keping Hu6Aibin He7Ying Luo8Jun Wang9Jinrong Peng10Fuchou Tang11Xiaojun Zhu12Jing-Wei Xiong13Institute of Molecular Medicine, Peking UniversityInstitute of Molecular Medicine, Peking UniversityBiodynamic Optical Imaging Center, Peking UniversitySchool of Life Sciences, University of Science and Technology of ChinaInstitute of Molecular Medicine, Peking UniversityDepartment of Biomedical Engineering, College of Engineering, Peking UniversityInstitute of Medicinal Plant Development, Chinese Academy of Medical SciencesInstitute of Molecular Medicine, Peking UniversityDepartment of Biomedical Engineering, College of Engineering, Peking UniversitySchool of Life Sciences, University of Science and Technology of ChinaCollege of Animal Sciences, Zhejiang UniversityBiodynamic Optical Imaging Center, Peking UniversityInstitute of Molecular Medicine, Peking UniversityInstitute of Molecular Medicine, Peking UniversityThe adult zebrafish heart is capable of regeneration but the molecular mechanisms are poorly understood. Here the authors show that chromatin remodeling factor Brg1 represses cyclin-dependent kinase inhibitors to promote myocardial regeneration.https://doi.org/10.1038/ncomms13787
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Chenglu Xiao Lu Gao Yu Hou Congfei Xu Nannan Chang Fang Wang Keping Hu Aibin He Ying Luo Jun Wang Jinrong Peng Fuchou Tang Xiaojun Zhu Jing-Wei Xiong
spellingShingle	Chenglu Xiao Lu Gao Yu Hou Congfei Xu Nannan Chang Fang Wang Keping Hu Aibin He Ying Luo Jun Wang Jinrong Peng Fuchou Tang Xiaojun Zhu Jing-Wei Xiong Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish Nature Communications
author_facet	Chenglu Xiao Lu Gao Yu Hou Congfei Xu Nannan Chang Fang Wang Keping Hu Aibin He Ying Luo Jun Wang Jinrong Peng Fuchou Tang Xiaojun Zhu Jing-Wei Xiong
author_sort	Chenglu Xiao
title	Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish
title_short	Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish
title_full	Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish
title_fullStr	Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish
title_full_unstemmed	Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish
title_sort	chromatin-remodelling factor brg1 regulates myocardial proliferation and regeneration in zebrafish
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-12-01
description	The adult zebrafish heart is capable of regeneration but the molecular mechanisms are poorly understood. Here the authors show that chromatin remodeling factor Brg1 represses cyclin-dependent kinase inhibitors to promote myocardial regeneration.
url	https://doi.org/10.1038/ncomms13787
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Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish

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