High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
Tran et al. combine high throughput sequencing, structural biology and computational simulation to determine the HLA allele and antibody-defined epitope frequencies in renal transplant patients and donors. These results demonstrate the feasibility of HLA epitope matching using data from a national t...
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Bibliographic Details
Main Authors: |
Jenny N. Tran,
Oliver P. Günther,
Karen R. Sherwood,
Franz Fenninger,
Lenka L. Allan,
James Lan,
Ruth Sapir-Pichhadze,
Rene Duquesnoy,
Frans Claas,
Steven G. E. Marsh,
W. Robert McMaster,
Paul A. Keown,
Genome Canada Transplant Consortium |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2021-05-01
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Series: | Communications Biology
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Online Access: | https://doi.org/10.1038/s42003-021-01989-3
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