High-throughput sequencing defines donor and recipient HLA B-cell epitope frequencies for prospective matching in transplantation
Tran et al. combine high throughput sequencing, structural biology and computational simulation to determine the HLA allele and antibody-defined epitope frequencies in renal transplant patients and donors. These results demonstrate the feasibility of HLA epitope matching using data from a national t...
Main Authors: | Jenny N. Tran, Oliver P. Günther, Karen R. Sherwood, Franz Fenninger, Lenka L. Allan, James Lan, Ruth Sapir-Pichhadze, Rene Duquesnoy, Frans Claas, Steven G. E. Marsh, W. Robert McMaster, Paul A. Keown, Genome Canada Transplant Consortium |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-05-01
|
Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-021-01989-3 |
Similar Items
-
Reflections on HLA Epitope-Based Matching for Transplantation
by: Rene J Duquesnoy
Published: (2016-11-01) -
Humoral Alloimmunity in Transplantation: Relevance of HLA Epitope Antigenicity and Immunogenicity
by: Rene J Duquesnoy
Published: (2011-11-01) -
Non-HLA Antibodies and Epitope Mismatches in Kidney Transplant Recipients With Histological Antibody-Mediated Rejection
by: Marta Crespo, et al.
Published: (2021-07-01) -
Usefulness of the nonself-self algorithm of HLA epitope immunogenicity in the specificity analysis of monospecific antibodies induced during pregnancy
by: Rene J Duquesnoy, et al.
Published: (2015-05-01) -
HLA Epitopes: The Targets of Monoclonal and Alloantibodies Defined
by: Nadim El-Awar, et al.
Published: (2017-01-01)