Gold Nanoparticle-Based Colorimetric Strategies for Chemical and Biological Sensing Applications

• Main Authors: Chia-Chen Chang, Chie-Pein Chen, Tzu-Heng Wu, Ching-Hsu Yang, Chii-Wann Lin, Chen-Yu Chen
• Format: Article
• Language: English
• Published: MDPI AG 2019-06-01
• Series: Nanomaterials
• Subjects: gold nanoparticle; colorimetric assay; aggregation of AuNPs; etching of AuNPs; growth of AuNPs; nanoenzyme
• Online Access: https://www.mdpi.com/2079-4991/9/6/861

Gold nanoparticles are popularly used in biological and chemical sensors and their applications owing to their fascinating chemical, optical, and catalytic properties. Particularly, the use of gold nanoparticles is widespread in colorimetric assays because of their simple, cost-effective fabrication, and ease of use. More importantly, the gold nanoparticle sensor response is a visual change in color, which allows easy interpretation of results. Therefore, many studies of gold nanoparticle-based colorimetric methods have been reported, and some review articles published over the past years. Most reviews focus exclusively on a single gold nanoparticle-based colorimetric technique for one analyte of interest. In this review, we focus on the current developments in different colorimetric assay designs for the sensing of various chemical and biological samples. We summarize and classify the sensing strategies and mechanism analyses of gold nanoparticle-based detection. Additionally, typical examples of recently developed gold nanoparticle-based colorimetric methods and their applications in the detection of various analytes are presented and discussed comprehensively.