Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) probably caused, in most cases, by the interaction of genetic and environmental factors. This review first summarizes some clinical, epidemiological and pathological characteristics of MS. Th...
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doaj-b95b7321c35943fabced36a3201c49ef2020-11-24T21:22:14ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-06-01196163910.3390/ijms19061639ijms19061639Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple SclerosisVéronique Ferret-Sena0Carlos Capela1Armando Sena2Centro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, 2819-511 Caparica, PortugalCentro Hospitalar de Lisboa Central, EPE, Hospital de Santo António dos Capuchos, Departamento de Neurociências, Alameda de Santo António dos Capuchos, 1169-050 Lisboa, PortugalCentro de Investigação Interdisciplinar Egas Moniz (CiiEM), Instituto Universitário Egas Moniz, Campus Universitário, Quinta da Granja, Monte de Caparica, 2819-511 Caparica, PortugalMultiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) probably caused, in most cases, by the interaction of genetic and environmental factors. This review first summarizes some clinical, epidemiological and pathological characteristics of MS. Then, the involvement of biochemical pathways is discussed in the development and repair of the CNS lesions and the immune dysfunction in the disease. Finally, the potential roles of peroxisome proliferator-activated receptors (PPAR) in MS are discussed. It is suggested that metabolic mechanisms modulated by PPAR provide a window to integrate the systemic and neurological events underlying the pathogenesis of the disease. In conclusion, the reviewed data highlight molecular avenues of understanding MS that may open new targets for improved therapies and preventive strategies for the disease.http://www.mdpi.com/1422-0067/19/6/1639multiple sclerosismetabolismperoxisome proliferator-activated receptorsimmune systemneuroinflammationneurodegeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Véronique Ferret-Sena Carlos Capela Armando Sena |
spellingShingle |
Véronique Ferret-Sena Carlos Capela Armando Sena Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis International Journal of Molecular Sciences multiple sclerosis metabolism peroxisome proliferator-activated receptors immune system neuroinflammation neurodegeneration |
author_facet |
Véronique Ferret-Sena Carlos Capela Armando Sena |
author_sort |
Véronique Ferret-Sena |
title |
Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis |
title_short |
Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis |
title_full |
Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis |
title_fullStr |
Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis |
title_full_unstemmed |
Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis |
title_sort |
metabolic dysfunction and peroxisome proliferator-activated receptors (ppar) in multiple sclerosis |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-06-01 |
description |
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) probably caused, in most cases, by the interaction of genetic and environmental factors. This review first summarizes some clinical, epidemiological and pathological characteristics of MS. Then, the involvement of biochemical pathways is discussed in the development and repair of the CNS lesions and the immune dysfunction in the disease. Finally, the potential roles of peroxisome proliferator-activated receptors (PPAR) in MS are discussed. It is suggested that metabolic mechanisms modulated by PPAR provide a window to integrate the systemic and neurological events underlying the pathogenesis of the disease. In conclusion, the reviewed data highlight molecular avenues of understanding MS that may open new targets for improved therapies and preventive strategies for the disease. |
topic |
multiple sclerosis metabolism peroxisome proliferator-activated receptors immune system neuroinflammation neurodegeneration |
url |
http://www.mdpi.com/1422-0067/19/6/1639 |
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1725996786456199168 |