Infectivity of human coronavirus in the brain
A new strain of human coronaviruses (hCoVs), Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been identified to be responsible for the current outbreak of the coronavirus disease 2019 (COVID-19). Though major symptoms are primarily generated from the respiratory system, neurologica...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2020-06-01
|
Series: | EBioMedicine |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396420301742 |
id |
doaj-b95eb4071d264e1e8733f3056ece188a |
---|---|
record_format |
Article |
spelling |
doaj-b95eb4071d264e1e8733f3056ece188a2020-11-25T03:39:18ZengElsevierEBioMedicine2352-39642020-06-0156102799Infectivity of human coronavirus in the brainQi Cheng0Yue Yang1Jianqun Gao2Department of Neurology and Neurophysiology, Liverpool Hospital, Sydney, New South Wales, Australia; Stroke and Neurology Research Group, Ingham Institute for Applied Medical Research, Sydney, New South Wales, AustraliaBrain and Mind Centre, Central Clinical School, the University of Sydney, Sydney, AustraliaBrain and Mind Centre, Central Clinical School, the University of Sydney, Sydney, Australia; Corresponding author.A new strain of human coronaviruses (hCoVs), Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been identified to be responsible for the current outbreak of the coronavirus disease 2019 (COVID-19). Though major symptoms are primarily generated from the respiratory system, neurological symptoms are being reported in some of the confirmed cases, raising concerns of its potential for intracranial invasion and neurological manifestations, both in the acute phase and in the long-term. At present, it remains unclear the extent to which SARS-CoV-2 is present in the brain, and if so, its pathogenic role in the central nervous system (CNS). Evidence for neuroinvasion and neurovirulence of hCoVs has been recognised in animal and human studies. Given that SARS-CoV-2 belongs to the same family and shares characteristics in terms of receptor binding properties, it is worthwhile exploring its potential CNS manifestations. This review summarises previous findings from hCoVs in relation to the CNS, and compares these with the new strain, aiming to provide a better understanding of the effects of SARS-CoV-2 on the CNS.http://www.sciencedirect.com/science/article/pii/S2352396420301742SARS-CoV-2CoronavirusHumanBrainNeuroinvasionNeurological manifestation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qi Cheng Yue Yang Jianqun Gao |
spellingShingle |
Qi Cheng Yue Yang Jianqun Gao Infectivity of human coronavirus in the brain EBioMedicine SARS-CoV-2 Coronavirus Human Brain Neuroinvasion Neurological manifestation |
author_facet |
Qi Cheng Yue Yang Jianqun Gao |
author_sort |
Qi Cheng |
title |
Infectivity of human coronavirus in the brain |
title_short |
Infectivity of human coronavirus in the brain |
title_full |
Infectivity of human coronavirus in the brain |
title_fullStr |
Infectivity of human coronavirus in the brain |
title_full_unstemmed |
Infectivity of human coronavirus in the brain |
title_sort |
infectivity of human coronavirus in the brain |
publisher |
Elsevier |
series |
EBioMedicine |
issn |
2352-3964 |
publishDate |
2020-06-01 |
description |
A new strain of human coronaviruses (hCoVs), Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been identified to be responsible for the current outbreak of the coronavirus disease 2019 (COVID-19). Though major symptoms are primarily generated from the respiratory system, neurological symptoms are being reported in some of the confirmed cases, raising concerns of its potential for intracranial invasion and neurological manifestations, both in the acute phase and in the long-term. At present, it remains unclear the extent to which SARS-CoV-2 is present in the brain, and if so, its pathogenic role in the central nervous system (CNS). Evidence for neuroinvasion and neurovirulence of hCoVs has been recognised in animal and human studies. Given that SARS-CoV-2 belongs to the same family and shares characteristics in terms of receptor binding properties, it is worthwhile exploring its potential CNS manifestations. This review summarises previous findings from hCoVs in relation to the CNS, and compares these with the new strain, aiming to provide a better understanding of the effects of SARS-CoV-2 on the CNS. |
topic |
SARS-CoV-2 Coronavirus Human Brain Neuroinvasion Neurological manifestation |
url |
http://www.sciencedirect.com/science/article/pii/S2352396420301742 |
work_keys_str_mv |
AT qicheng infectivityofhumancoronavirusinthebrain AT yueyang infectivityofhumancoronavirusinthebrain AT jianqungao infectivityofhumancoronavirusinthebrain |
_version_ |
1724539629355401216 |