Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine
Evaluation of the efficacy of traditional Chinese medicines (TCMs) is an important prerequisite for discovering effective substances, lead compounds, and quality markers (Q markers). At present, there is an urgent need to develop a biological language that can act as abridge for the scientific elabo...
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doaj-b96617bee41047fdbcf913503bb6cfa52020-11-24T22:00:32ZengElsevierEngineering2095-80992019-02-01516068Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese MedicineAi-Hua Zhang0Hui Sun1Guang-Li Yan2Ying Han3Qi-Qi Zhao4Xi-Jun Wang5National Chinmedomics Research Center & Sino-America Chinmedomics Technology Collaboration Center & National TCM Key Laboratory of Serum Pharmacochemistry & Laboratory of Metabolomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaNational Chinmedomics Research Center & Sino-America Chinmedomics Technology Collaboration Center & National TCM Key Laboratory of Serum Pharmacochemistry & Laboratory of Metabolomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaNational Chinmedomics Research Center & Sino-America Chinmedomics Technology Collaboration Center & National TCM Key Laboratory of Serum Pharmacochemistry & Laboratory of Metabolomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaNational Chinmedomics Research Center & Sino-America Chinmedomics Technology Collaboration Center & National TCM Key Laboratory of Serum Pharmacochemistry & Laboratory of Metabolomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaNational Chinmedomics Research Center & Sino-America Chinmedomics Technology Collaboration Center & National TCM Key Laboratory of Serum Pharmacochemistry & Laboratory of Metabolomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaCorresponding author.; National Chinmedomics Research Center & Sino-America Chinmedomics Technology Collaboration Center & National TCM Key Laboratory of Serum Pharmacochemistry & Laboratory of Metabolomics, Department of Pharmaceutical Analysis, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaEvaluation of the efficacy of traditional Chinese medicines (TCMs) is an important prerequisite for discovering effective substances, lead compounds, and quality markers (Q markers). At present, there is an urgent need to develop a biological language that can act as abridge for the scientific elaboration of the efficacy of TCMs, and to further highlight the significant value of TCM. Chinese medicinal syndromes and formulae are two essential parts of TCM that directly relate to its efficacy. Syndromes and formulae have been taken as the research objects. The serum pharmacochemistry of the TCM approach with metabolomics were integrated to establish an innovative chinmedomics strategy, which is able to explore syndrome biomarkers and evaluate TCM efficacy in order to discover effective substances from TCMs. A great deal of concrete work in chinmedomics has already performed to bridge the gap between Chinese and Western medicine, and to provide a powerful approach to enhance the scientific value of TCM theory and clinical practice. This article summarizes the application of chinmedomics in identifying the candidate biomarkers of a syndrome and revealing the efficacy of the related formula. We also highlight the discovery of lead compounds and Q markers from TCMs. Keywords: Chinmedomics, Serum pharmacochemistry of TCM, Efficacy, Metabolomics, Syndrome, Biomarkers, Quality markershttp://www.sciencedirect.com/science/article/pii/S2095809918304922 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ai-Hua Zhang Hui Sun Guang-Li Yan Ying Han Qi-Qi Zhao Xi-Jun Wang |
spellingShingle |
Ai-Hua Zhang Hui Sun Guang-Li Yan Ying Han Qi-Qi Zhao Xi-Jun Wang Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine Engineering |
author_facet |
Ai-Hua Zhang Hui Sun Guang-Li Yan Ying Han Qi-Qi Zhao Xi-Jun Wang |
author_sort |
Ai-Hua Zhang |
title |
Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine |
title_short |
Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine |
title_full |
Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine |
title_fullStr |
Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine |
title_full_unstemmed |
Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine |
title_sort |
chinmedomics: a powerful approach integrating metabolomics with serum pharmacochemistry to evaluate the efficacy of traditional chinese medicine |
publisher |
Elsevier |
series |
Engineering |
issn |
2095-8099 |
publishDate |
2019-02-01 |
description |
Evaluation of the efficacy of traditional Chinese medicines (TCMs) is an important prerequisite for discovering effective substances, lead compounds, and quality markers (Q markers). At present, there is an urgent need to develop a biological language that can act as abridge for the scientific elaboration of the efficacy of TCMs, and to further highlight the significant value of TCM. Chinese medicinal syndromes and formulae are two essential parts of TCM that directly relate to its efficacy. Syndromes and formulae have been taken as the research objects. The serum pharmacochemistry of the TCM approach with metabolomics were integrated to establish an innovative chinmedomics strategy, which is able to explore syndrome biomarkers and evaluate TCM efficacy in order to discover effective substances from TCMs. A great deal of concrete work in chinmedomics has already performed to bridge the gap between Chinese and Western medicine, and to provide a powerful approach to enhance the scientific value of TCM theory and clinical practice. This article summarizes the application of chinmedomics in identifying the candidate biomarkers of a syndrome and revealing the efficacy of the related formula. We also highlight the discovery of lead compounds and Q markers from TCMs. Keywords: Chinmedomics, Serum pharmacochemistry of TCM, Efficacy, Metabolomics, Syndrome, Biomarkers, Quality markers |
url |
http://www.sciencedirect.com/science/article/pii/S2095809918304922 |
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