In-vivo dosimetric analysis in total skin electron beam therapy
Background and purpose: Thermoluminescent dosimetry (TLD) is an important element of total skin electron beam therapy (TSEBT). In this study, we compare radiation dose distributions to provide data for dose variation across anatomic sites. Materials and methods: Retrospectively collected data on 85...
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doaj-b973fe88a7b34560abf04549f526d6082020-11-24T23:41:30ZengElsevierPhysics and Imaging in Radiation Oncology2405-63162018-04-0166165In-vivo dosimetric analysis in total skin electron beam therapyKhaled Elsayad0Christos Moustakis1Manuela Simonsen2Dagmar Bäcker3Uwe Haverkamp4Hans Theodor Eich5Corresponding author at: Department of Radiation Oncology, University Hospital of Münster, Building A1, 1 Albert Schweitzer Campus, 48149 Münster, Germany.; Department of Radiation Oncology, University Hospital of Münster, Münster, GermanyDepartment of Radiation Oncology, University Hospital of Münster, Münster, GermanyDepartment of Radiation Oncology, University Hospital of Münster, Münster, GermanyDepartment of Radiation Oncology, University Hospital of Münster, Münster, GermanyDepartment of Radiation Oncology, University Hospital of Münster, Münster, GermanyDepartment of Radiation Oncology, University Hospital of Münster, Münster, GermanyBackground and purpose: Thermoluminescent dosimetry (TLD) is an important element of total skin electron beam therapy (TSEBT). In this study, we compare radiation dose distributions to provide data for dose variation across anatomic sites. Materials and methods: Retrospectively collected data on 85 patients with cutaneous lymphoma or leukemia underwent TSEBT were reviewed. Patients were irradiated on two linear accelerators, in one of two positions (standing, n = 77; reclined, n = 8) and 1830 in vivo TLD measurements were obtained for various locations on 76 patients. Results: The TLD results showed that the two TSEBT techniques were dosimetrically heterogeneous. At several sites, the dose administered correlated with height, weight, and gender. After the first TLD measurement, fourteen patients (18%) required MU modification, with a mean 10% reduction (range, −25 to +35). Individual TLD results allowed us to customize the boost treatment for each patient. For patients who were evaluated in the standing position, the most common underdosed sites were the axilla, perineum/perianal folds, and soles (each receiving 69%, 20%, and 34% of the prescribed dose, respectively). For patients evaluated in a reclining position, surface dose distribution was more heterogeneous. The sites underdosed most commonly were the axilla and perineum/perianal folds (receiving less than one third of prescribed dose). Significant variables were detected with model building. Conclusion: TLD measurements were integral to quality assurance for TSEBT. Dose distribution at several anatomical sites correlated significantly with gender, height, and weight of the treated individual and might be predicted. Keywords: Dosimeter, Cutaneous lymphoma, Leukemia cutis, Mycosis fungoides, Dose distribution, Total skin electron beamhttp://www.sciencedirect.com/science/article/pii/S2405631617300829 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Khaled Elsayad Christos Moustakis Manuela Simonsen Dagmar Bäcker Uwe Haverkamp Hans Theodor Eich |
spellingShingle |
Khaled Elsayad Christos Moustakis Manuela Simonsen Dagmar Bäcker Uwe Haverkamp Hans Theodor Eich In-vivo dosimetric analysis in total skin electron beam therapy Physics and Imaging in Radiation Oncology |
author_facet |
Khaled Elsayad Christos Moustakis Manuela Simonsen Dagmar Bäcker Uwe Haverkamp Hans Theodor Eich |
author_sort |
Khaled Elsayad |
title |
In-vivo dosimetric analysis in total skin electron beam therapy |
title_short |
In-vivo dosimetric analysis in total skin electron beam therapy |
title_full |
In-vivo dosimetric analysis in total skin electron beam therapy |
title_fullStr |
In-vivo dosimetric analysis in total skin electron beam therapy |
title_full_unstemmed |
In-vivo dosimetric analysis in total skin electron beam therapy |
title_sort |
in-vivo dosimetric analysis in total skin electron beam therapy |
publisher |
Elsevier |
series |
Physics and Imaging in Radiation Oncology |
issn |
2405-6316 |
publishDate |
2018-04-01 |
description |
Background and purpose: Thermoluminescent dosimetry (TLD) is an important element of total skin electron beam therapy (TSEBT). In this study, we compare radiation dose distributions to provide data for dose variation across anatomic sites. Materials and methods: Retrospectively collected data on 85 patients with cutaneous lymphoma or leukemia underwent TSEBT were reviewed. Patients were irradiated on two linear accelerators, in one of two positions (standing, n = 77; reclined, n = 8) and 1830 in vivo TLD measurements were obtained for various locations on 76 patients. Results: The TLD results showed that the two TSEBT techniques were dosimetrically heterogeneous. At several sites, the dose administered correlated with height, weight, and gender. After the first TLD measurement, fourteen patients (18%) required MU modification, with a mean 10% reduction (range, −25 to +35). Individual TLD results allowed us to customize the boost treatment for each patient. For patients who were evaluated in the standing position, the most common underdosed sites were the axilla, perineum/perianal folds, and soles (each receiving 69%, 20%, and 34% of the prescribed dose, respectively). For patients evaluated in a reclining position, surface dose distribution was more heterogeneous. The sites underdosed most commonly were the axilla and perineum/perianal folds (receiving less than one third of prescribed dose). Significant variables were detected with model building. Conclusion: TLD measurements were integral to quality assurance for TSEBT. Dose distribution at several anatomical sites correlated significantly with gender, height, and weight of the treated individual and might be predicted. Keywords: Dosimeter, Cutaneous lymphoma, Leukemia cutis, Mycosis fungoides, Dose distribution, Total skin electron beam |
url |
http://www.sciencedirect.com/science/article/pii/S2405631617300829 |
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