Post-exercise serum hepcidin levels were unaffected by hypoxic exposure during prolonged exercise sessions.
The purpose of the present study was to determine the influence of hypoxic exposure during prolonged endurance exercise sessions (79 min in total) on post-exercise hepcidin levels in trained male endurance athletes. Ten endurance athletes (mean ± standard deviation; height: 169.8 ± 7.1 cm, weight: 5...
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doaj-b979be6f0b8249fda396e20ff95fd0002020-11-24T22:17:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01128e018362910.1371/journal.pone.0183629Post-exercise serum hepcidin levels were unaffected by hypoxic exposure during prolonged exercise sessions.Kazushige GotoDaichi SumiChihiro KojimaAya IshibashiThe purpose of the present study was to determine the influence of hypoxic exposure during prolonged endurance exercise sessions (79 min in total) on post-exercise hepcidin levels in trained male endurance athletes. Ten endurance athletes (mean ± standard deviation; height: 169.8 ± 7.1 cm, weight: 57.1 ± 5.0 kg) conducted two endurance exercise sessions under either a normobaric hypoxic condition [inspired O2 fraction (FiO2) = 14.5%] or a normoxic condition (FiO2 = 20.9%). Exercise consisted of 10 × 3 min running on a treadmill at 95% of maximal oxygen uptake ([Formula: see text]) with 60s of active rest at 60% of [Formula: see text]. After 10 min of rest, they subsequently performed 30 min of continuous running at 85% of [Formula: see text]. Running velocities were significantly lower in the HYPO than in the NOR (P < 0.0001). Exercise-induced blood lactate elevation was significantly greater in the HYPO (P < 0.01). There were significant increases in plasma interleukin-6, serum iron, and blood glucose levels after exercise, with no significant difference between the trials [interaction (trial × time) or main effect for trial, P > 0.05]. Serum hepcidin levels increased significantly 120 min after exercise (HYPO: from 10.7 ± 9.4 ng/mL to 15.8 ± 11.2 ng/mL; NOR: from 7.9 ± 4.7 ng/mL to 13.2 ± 7.9 ng/mL, P < 0.05), and no difference was observed between the trials. In conclusion, endurance exercise at lower running velocity in hypoxic conditions resulted in similar post-exercise hepcidin elevations as higher running velocity in normoxic conditions.http://europepmc.org/articles/PMC5567555?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kazushige Goto Daichi Sumi Chihiro Kojima Aya Ishibashi |
spellingShingle |
Kazushige Goto Daichi Sumi Chihiro Kojima Aya Ishibashi Post-exercise serum hepcidin levels were unaffected by hypoxic exposure during prolonged exercise sessions. PLoS ONE |
author_facet |
Kazushige Goto Daichi Sumi Chihiro Kojima Aya Ishibashi |
author_sort |
Kazushige Goto |
title |
Post-exercise serum hepcidin levels were unaffected by hypoxic exposure during prolonged exercise sessions. |
title_short |
Post-exercise serum hepcidin levels were unaffected by hypoxic exposure during prolonged exercise sessions. |
title_full |
Post-exercise serum hepcidin levels were unaffected by hypoxic exposure during prolonged exercise sessions. |
title_fullStr |
Post-exercise serum hepcidin levels were unaffected by hypoxic exposure during prolonged exercise sessions. |
title_full_unstemmed |
Post-exercise serum hepcidin levels were unaffected by hypoxic exposure during prolonged exercise sessions. |
title_sort |
post-exercise serum hepcidin levels were unaffected by hypoxic exposure during prolonged exercise sessions. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
The purpose of the present study was to determine the influence of hypoxic exposure during prolonged endurance exercise sessions (79 min in total) on post-exercise hepcidin levels in trained male endurance athletes. Ten endurance athletes (mean ± standard deviation; height: 169.8 ± 7.1 cm, weight: 57.1 ± 5.0 kg) conducted two endurance exercise sessions under either a normobaric hypoxic condition [inspired O2 fraction (FiO2) = 14.5%] or a normoxic condition (FiO2 = 20.9%). Exercise consisted of 10 × 3 min running on a treadmill at 95% of maximal oxygen uptake ([Formula: see text]) with 60s of active rest at 60% of [Formula: see text]. After 10 min of rest, they subsequently performed 30 min of continuous running at 85% of [Formula: see text]. Running velocities were significantly lower in the HYPO than in the NOR (P < 0.0001). Exercise-induced blood lactate elevation was significantly greater in the HYPO (P < 0.01). There were significant increases in plasma interleukin-6, serum iron, and blood glucose levels after exercise, with no significant difference between the trials [interaction (trial × time) or main effect for trial, P > 0.05]. Serum hepcidin levels increased significantly 120 min after exercise (HYPO: from 10.7 ± 9.4 ng/mL to 15.8 ± 11.2 ng/mL; NOR: from 7.9 ± 4.7 ng/mL to 13.2 ± 7.9 ng/mL, P < 0.05), and no difference was observed between the trials. In conclusion, endurance exercise at lower running velocity in hypoxic conditions resulted in similar post-exercise hepcidin elevations as higher running velocity in normoxic conditions. |
url |
http://europepmc.org/articles/PMC5567555?pdf=render |
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