Hepatic Sarcoidosis Presenting as Portal Hypertension and Liver Cirrhosis: Case Report and Review of the Literature

Systemic sarcoidosis is a disease of unknown etiology, with the liver being the third most commonly affected organ. Most cases of hepatic sarcoidosis are not clinically apparent, but a few can progress to liver cirrhosis, portal hypertension and ultimately liver failure. The diagnosis of hepatic sar...

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Main Authors: Christopher B. Tan, Sadat Rashid, Dhyan Rajan, Wondwoosen Gebre, Paul Mustacchia
Format: Article
Language:English
Published: Karger Publishers 2012-04-01
Series:Case Reports in Gastroenterology
Subjects:
Online Access:http://www.karger.com/Article/FullText/338355
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spelling doaj-b97c18d6113c4bf4b09f2ec29edbd2662020-11-24T20:41:36ZengKarger PublishersCase Reports in Gastroenterology1662-06312012-04-016118318910.1159/000338355338355Hepatic Sarcoidosis Presenting as Portal Hypertension and Liver Cirrhosis: Case Report and Review of the LiteratureChristopher B. TanSadat RashidDhyan RajanWondwoosen GebrePaul MustacchiaSystemic sarcoidosis is a disease of unknown etiology, with the liver being the third most commonly affected organ. Most cases of hepatic sarcoidosis are not clinically apparent, but a few can progress to liver cirrhosis, portal hypertension and ultimately liver failure. The diagnosis of hepatic sarcoidosis is difficult, considering that no single laboratory test or radiographic finding can definitively diagnose this systemic disease. Diagnosis of hepatic sarcoidosis relies heavily on histopathologic evaluation of two or more organs, a diagnostic modality that is invasive and may not be applicable to all patients. The treatment of hepatic sarcoidosis is challenging, with no large randomized controlled trials done to date. Physicians must be aware of the complications of hepatic sarcoidosis, and must include the same in the differential diagnosis of liver cirrhosis. We present a case of hepatic sarcoidosis complicated by portal hypertension and liver cirrhosis.http://www.karger.com/Article/FullText/338355Portal hypertensionGastrointestinal sarcoidosisExtrapulmonary sarcoidosisHepatic sarcoidosis and liver cirrhosisHepatic sarcoidosis and portal hypertensionHepatic sarcoidosisLiver cirrhosis
collection DOAJ
language English
format Article
sources DOAJ
author Christopher B. Tan
Sadat Rashid
Dhyan Rajan
Wondwoosen Gebre
Paul Mustacchia
spellingShingle Christopher B. Tan
Sadat Rashid
Dhyan Rajan
Wondwoosen Gebre
Paul Mustacchia
Hepatic Sarcoidosis Presenting as Portal Hypertension and Liver Cirrhosis: Case Report and Review of the Literature
Case Reports in Gastroenterology
Portal hypertension
Gastrointestinal sarcoidosis
Extrapulmonary sarcoidosis
Hepatic sarcoidosis and liver cirrhosis
Hepatic sarcoidosis and portal hypertension
Hepatic sarcoidosis
Liver cirrhosis
author_facet Christopher B. Tan
Sadat Rashid
Dhyan Rajan
Wondwoosen Gebre
Paul Mustacchia
author_sort Christopher B. Tan
title Hepatic Sarcoidosis Presenting as Portal Hypertension and Liver Cirrhosis: Case Report and Review of the Literature
title_short Hepatic Sarcoidosis Presenting as Portal Hypertension and Liver Cirrhosis: Case Report and Review of the Literature
title_full Hepatic Sarcoidosis Presenting as Portal Hypertension and Liver Cirrhosis: Case Report and Review of the Literature
title_fullStr Hepatic Sarcoidosis Presenting as Portal Hypertension and Liver Cirrhosis: Case Report and Review of the Literature
title_full_unstemmed Hepatic Sarcoidosis Presenting as Portal Hypertension and Liver Cirrhosis: Case Report and Review of the Literature
title_sort hepatic sarcoidosis presenting as portal hypertension and liver cirrhosis: case report and review of the literature
publisher Karger Publishers
series Case Reports in Gastroenterology
issn 1662-0631
publishDate 2012-04-01
description Systemic sarcoidosis is a disease of unknown etiology, with the liver being the third most commonly affected organ. Most cases of hepatic sarcoidosis are not clinically apparent, but a few can progress to liver cirrhosis, portal hypertension and ultimately liver failure. The diagnosis of hepatic sarcoidosis is difficult, considering that no single laboratory test or radiographic finding can definitively diagnose this systemic disease. Diagnosis of hepatic sarcoidosis relies heavily on histopathologic evaluation of two or more organs, a diagnostic modality that is invasive and may not be applicable to all patients. The treatment of hepatic sarcoidosis is challenging, with no large randomized controlled trials done to date. Physicians must be aware of the complications of hepatic sarcoidosis, and must include the same in the differential diagnosis of liver cirrhosis. We present a case of hepatic sarcoidosis complicated by portal hypertension and liver cirrhosis.
topic Portal hypertension
Gastrointestinal sarcoidosis
Extrapulmonary sarcoidosis
Hepatic sarcoidosis and liver cirrhosis
Hepatic sarcoidosis and portal hypertension
Hepatic sarcoidosis
Liver cirrhosis
url http://www.karger.com/Article/FullText/338355
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AT sadatrashid hepaticsarcoidosispresentingasportalhypertensionandlivercirrhosiscasereportandreviewoftheliterature
AT dhyanrajan hepaticsarcoidosispresentingasportalhypertensionandlivercirrhosiscasereportandreviewoftheliterature
AT wondwoosengebre hepaticsarcoidosispresentingasportalhypertensionandlivercirrhosiscasereportandreviewoftheliterature
AT paulmustacchia hepaticsarcoidosispresentingasportalhypertensionandlivercirrhosiscasereportandreviewoftheliterature
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