Macrophage-released ADAMTS1 promotes muscle stem cell activation

Satellite cells are crucial for growth and regeneration of skeletal muscle. Here the authors show that in response to muscle injury, macrophages secrete Adamts1, which induces satellite cell activation by modulating Notch1 signaling.

Bibliographic Details
Main Authors:	Hongqing Du, Chung-Hsuan Shih, Michael N. Wosczyna, Alisa A. Mueller, Joonseok Cho, Abhishek Aggarwal, Thomas A. Rando, Brian J. Feldman
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-017-00522-7

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spelling	doaj-b985b4346d2b4425bb7a38b75908eb782021-05-11T07:09:24ZengNature Publishing GroupNature Communications2041-17232017-09-018111110.1038/s41467-017-00522-7Macrophage-released ADAMTS1 promotes muscle stem cell activationHongqing Du0Chung-Hsuan Shih1Michael N. Wosczyna2Alisa A. Mueller3Joonseok Cho4Abhishek Aggarwal5Thomas A. Rando6Brian J. Feldman7Department of Pediatrics, Stanford UniversityDepartment of Pediatrics, Stanford UniversityDepartment of Neurology and Neurological Sciences, Stanford UniversityDepartment of Neurology and Neurological Sciences, Stanford UniversityDepartment of Pediatrics, Stanford UniversityDepartment of Pediatrics, Stanford UniversityDepartment of Neurology and Neurological Sciences, Stanford UniversityDepartment of Pediatrics, Stanford UniversitySatellite cells are crucial for growth and regeneration of skeletal muscle. Here the authors show that in response to muscle injury, macrophages secrete Adamts1, which induces satellite cell activation by modulating Notch1 signaling.https://doi.org/10.1038/s41467-017-00522-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hongqing Du Chung-Hsuan Shih Michael N. Wosczyna Alisa A. Mueller Joonseok Cho Abhishek Aggarwal Thomas A. Rando Brian J. Feldman
spellingShingle	Hongqing Du Chung-Hsuan Shih Michael N. Wosczyna Alisa A. Mueller Joonseok Cho Abhishek Aggarwal Thomas A. Rando Brian J. Feldman Macrophage-released ADAMTS1 promotes muscle stem cell activation Nature Communications
author_facet	Hongqing Du Chung-Hsuan Shih Michael N. Wosczyna Alisa A. Mueller Joonseok Cho Abhishek Aggarwal Thomas A. Rando Brian J. Feldman
author_sort	Hongqing Du
title	Macrophage-released ADAMTS1 promotes muscle stem cell activation
title_short	Macrophage-released ADAMTS1 promotes muscle stem cell activation
title_full	Macrophage-released ADAMTS1 promotes muscle stem cell activation
title_fullStr	Macrophage-released ADAMTS1 promotes muscle stem cell activation
title_full_unstemmed	Macrophage-released ADAMTS1 promotes muscle stem cell activation
title_sort	macrophage-released adamts1 promotes muscle stem cell activation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-09-01
description	Satellite cells are crucial for growth and regeneration of skeletal muscle. Here the authors show that in response to muscle injury, macrophages secrete Adamts1, which induces satellite cell activation by modulating Notch1 signaling.
url	https://doi.org/10.1038/s41467-017-00522-7
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Macrophage-released ADAMTS1 promotes muscle stem cell activation

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