Targeting Galectins With Glycomimetics
Among glycan-binding proteins, galectins, β-galactoside-binding lectins, exhibit relevant biological roles and are implicated in many diseases, such as cancer and inflammation. Their involvement in crucial pathologies makes them interesting targets for drug discovery. In this review, we gather the l...
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doaj-b9888bc8ebe64bb4a5cd88a473b703262020-11-25T03:26:29ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462020-08-01810.3389/fchem.2020.00593552915Targeting Galectins With GlycomimeticsSara Bertuzzi0Jon I. Quintana1Ana Ardá2Ana Gimeno3Jesús Jiménez-Barbero4Jesús Jiménez-Barbero5Jesús Jiménez-Barbero6CIC bioGUNE, Basque Research Technology Alliance, Derio, SpainCIC bioGUNE, Basque Research Technology Alliance, Derio, SpainCIC bioGUNE, Basque Research Technology Alliance, Derio, SpainCIC bioGUNE, Basque Research Technology Alliance, Derio, SpainCIC bioGUNE, Basque Research Technology Alliance, Derio, SpainIkerbasque, Basque Foundation for Science, Bilbao, SpainDepartment of Organic Chemistry II, Faculty of Science and Technology, University of the Basque Country - UPV-EHU, Leioa, SpainAmong glycan-binding proteins, galectins, β-galactoside-binding lectins, exhibit relevant biological roles and are implicated in many diseases, such as cancer and inflammation. Their involvement in crucial pathologies makes them interesting targets for drug discovery. In this review, we gather the last approaches toward the specific design of glycomimetics as potential drugs against galectins. Different approaches, either using specific glycomimetic molecules decorated with key functional groups or employing multivalent presentations of lactose and N-acetyl lactosamine analogs, have provided promising results for binding and modulating different galectins. The review highlights the results obtained with these approximations, from the employment of S-glycosyl compounds to peptidomimetics and multivalent glycopolymers, mostly employed to recognize and/or detect hGal-1 and hGal-3.https://www.frontiersin.org/article/10.3389/fchem.2020.00593/fullgalectinsglycomimeticsglycansmolecular recogntiondrug design |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sara Bertuzzi Jon I. Quintana Ana Ardá Ana Gimeno Jesús Jiménez-Barbero Jesús Jiménez-Barbero Jesús Jiménez-Barbero |
spellingShingle |
Sara Bertuzzi Jon I. Quintana Ana Ardá Ana Gimeno Jesús Jiménez-Barbero Jesús Jiménez-Barbero Jesús Jiménez-Barbero Targeting Galectins With Glycomimetics Frontiers in Chemistry galectins glycomimetics glycans molecular recogntion drug design |
author_facet |
Sara Bertuzzi Jon I. Quintana Ana Ardá Ana Gimeno Jesús Jiménez-Barbero Jesús Jiménez-Barbero Jesús Jiménez-Barbero |
author_sort |
Sara Bertuzzi |
title |
Targeting Galectins With Glycomimetics |
title_short |
Targeting Galectins With Glycomimetics |
title_full |
Targeting Galectins With Glycomimetics |
title_fullStr |
Targeting Galectins With Glycomimetics |
title_full_unstemmed |
Targeting Galectins With Glycomimetics |
title_sort |
targeting galectins with glycomimetics |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Chemistry |
issn |
2296-2646 |
publishDate |
2020-08-01 |
description |
Among glycan-binding proteins, galectins, β-galactoside-binding lectins, exhibit relevant biological roles and are implicated in many diseases, such as cancer and inflammation. Their involvement in crucial pathologies makes them interesting targets for drug discovery. In this review, we gather the last approaches toward the specific design of glycomimetics as potential drugs against galectins. Different approaches, either using specific glycomimetic molecules decorated with key functional groups or employing multivalent presentations of lactose and N-acetyl lactosamine analogs, have provided promising results for binding and modulating different galectins. The review highlights the results obtained with these approximations, from the employment of S-glycosyl compounds to peptidomimetics and multivalent glycopolymers, mostly employed to recognize and/or detect hGal-1 and hGal-3. |
topic |
galectins glycomimetics glycans molecular recogntion drug design |
url |
https://www.frontiersin.org/article/10.3389/fchem.2020.00593/full |
work_keys_str_mv |
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