Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates
Abstract The gold rush in the Amazon Region caused an increase of mercury (Hg) levels in the environment, and, consequently, raised human exposure. Once released into aquatic systems, Hg could generate methylmercury (MeHg), an extremely toxic compound, which is accumulated through trophic chains. Se...
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Associação Brasileira de Pós-Graduação em Saúde Coletiva
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doaj-b9892d83be794c488d30a5dd960f133d2020-11-24T21:06:00ZengAssociação Brasileira de Pós-Graduação em Saúde ColetivaCiência & Saúde Coletiva1678-456123113535354510.1590/1413-812320182311.15812016S1413-81232018001103535Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimatesAna Claudia Santiago de VasconcellosPaulo Rubens Guimarães BarrocasClaudia Maribel Vega RuizDennys de Souza MourãoSandra de Souza HaconAbstract The gold rush in the Amazon Region caused an increase of mercury (Hg) levels in the environment, and, consequently, raised human exposure. Once released into aquatic systems, Hg could generate methylmercury (MeHg), an extremely toxic compound, which is accumulated through trophic chains. Several studies have provided evidences of the brain sensitivity to MeHg, as well as, of the fetus vulnerability during pregnancy. The main objective of this study was to estimate the Mild Mental Retardation (MMR) in Amazonian populations, caused by prenatal exposure to MeHg, using the methodology proposed by Poulin (2008), which quantifies the environmental burden of disease. The estimates of the MMR burden, attributed to prenatal MeHg exposure, were based on the calculation of Disability-Adjusted Life Years (DALY), which were obtained from MMR incidence rate in the studied populations. At the local level, the MMR incidence rate calculations were based on primary data of MeHg exposure of riverine women at childbearing age. The MMR incidence rate was equal to 5.96/1,000 infants, which would result in 2.0 IQ points loss in 34.31% of the newborns. The estimated DALY/1,000 infants was equal to 71.2, while the DALY was 576. For the regional estimates, different exposure scenarios were created. The calculated DALY varied from 3,256 to 65,952 per year.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232018001103535&lng=en&tlng=enHgDALYAmazônia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana Claudia Santiago de Vasconcellos Paulo Rubens Guimarães Barrocas Claudia Maribel Vega Ruiz Dennys de Souza Mourão Sandra de Souza Hacon |
spellingShingle |
Ana Claudia Santiago de Vasconcellos Paulo Rubens Guimarães Barrocas Claudia Maribel Vega Ruiz Dennys de Souza Mourão Sandra de Souza Hacon Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates Ciência & Saúde Coletiva Hg DALY Amazônia |
author_facet |
Ana Claudia Santiago de Vasconcellos Paulo Rubens Guimarães Barrocas Claudia Maribel Vega Ruiz Dennys de Souza Mourão Sandra de Souza Hacon |
author_sort |
Ana Claudia Santiago de Vasconcellos |
title |
Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates |
title_short |
Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates |
title_full |
Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates |
title_fullStr |
Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates |
title_full_unstemmed |
Burden of Mild Mental Retardation attributed to prenatal methylmercury exposure in Amazon: local and regional estimates |
title_sort |
burden of mild mental retardation attributed to prenatal methylmercury exposure in amazon: local and regional estimates |
publisher |
Associação Brasileira de Pós-Graduação em Saúde Coletiva |
series |
Ciência & Saúde Coletiva |
issn |
1678-4561 |
description |
Abstract The gold rush in the Amazon Region caused an increase of mercury (Hg) levels in the environment, and, consequently, raised human exposure. Once released into aquatic systems, Hg could generate methylmercury (MeHg), an extremely toxic compound, which is accumulated through trophic chains. Several studies have provided evidences of the brain sensitivity to MeHg, as well as, of the fetus vulnerability during pregnancy. The main objective of this study was to estimate the Mild Mental Retardation (MMR) in Amazonian populations, caused by prenatal exposure to MeHg, using the methodology proposed by Poulin (2008), which quantifies the environmental burden of disease. The estimates of the MMR burden, attributed to prenatal MeHg exposure, were based on the calculation of Disability-Adjusted Life Years (DALY), which were obtained from MMR incidence rate in the studied populations. At the local level, the MMR incidence rate calculations were based on primary data of MeHg exposure of riverine women at childbearing age. The MMR incidence rate was equal to 5.96/1,000 infants, which would result in 2.0 IQ points loss in 34.31% of the newborns. The estimated DALY/1,000 infants was equal to 71.2, while the DALY was 576. For the regional estimates, different exposure scenarios were created. The calculated DALY varied from 3,256 to 65,952 per year. |
topic |
Hg DALY Amazônia |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232018001103535&lng=en&tlng=en |
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