Development of Near Infrared-Fluorescent Nanophosphors and Applications for Cancer Diagnosis and Therapy

Development of Near Infrared-Fluorescent Nanophosphors and Applications for Cancer Diagnosis and Therapy

The use of near infrared (NIR) light for biomedical photonics in the wavelength region between 800 and 2000 nm, which is called “biological window”, has received particular attention since water and biological tissues have minimal optical loss due to scattering and absorption as well as autofluoresc...

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Main Authors: Tamotsu Zako, Hiroshi Hyodo, Kosuke Tsuji, Kimikazu Tokuzen, Hidehiro Kishimoto, Masaaki Ito, Kazuhiro Kaneko, Mizuo Maeda, Kohei Soga
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Journal of Nanomaterials
Online Access:http://dx.doi.org/10.1155/2010/491471
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spelling doaj-b98959c67430495facc1060c6fdbe6352020-11-24T23:15:13ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292010-01-01201010.1155/2010/491471491471Development of Near Infrared-Fluorescent Nanophosphors and Applications for Cancer Diagnosis and TherapyTamotsu Zako0Hiroshi Hyodo1Kosuke Tsuji2Kimikazu Tokuzen3Hidehiro Kishimoto4Masaaki Ito5Kazuhiro Kaneko6Mizuo Maeda7Kohei Soga8Bioengineering Laboratory, RIKEN Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, JapanDepartment of Material Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, JapanDepartment of Material Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, JapanDepartment of Material Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, JapanCenter for Technologies against Cancer, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, JapanDepartment of Colorectal and Pelvic Surgery, National Cancer Center Hospital East, Kashiwanoha 6-5-1, Kashiwa, Chiba 277-8577, JapanDivision of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwanoha 6-5-1, Kashiwa, Chiba 277-8577, JapanBioengineering Laboratory, RIKEN Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, JapanDepartment of Material Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, JapanThe use of near infrared (NIR) light for biomedical photonics in the wavelength region between 800 and 2000 nm, which is called “biological window”, has received particular attention since water and biological tissues have minimal optical loss due to scattering and absorption as well as autofluorescence in this region. Recent development of InGaAs CCD enables observations in this wavelength region. In the present paper, we report development of Yb and Er-doped yttrium oxide nanoparticles (Y2O3:YbEr-NP) which show strong NIR emission under NIR excitation (NIR-NIR emission). We also demonstrate that NIR emission can be observed through swine colon wall. Based on these results, we propose a possible application of Y2O3:YbEr-NP for cancer diagnosis and therapy using NIR-NIR imaging system. Our results also suggest potential applications of Y2O3:YbEr-NP for noninvasive detection of various diseases.http://dx.doi.org/10.1155/2010/491471
collection DOAJ
language English
format Article
sources DOAJ
author Tamotsu Zako
Hiroshi Hyodo
Kosuke Tsuji
Kimikazu Tokuzen
Hidehiro Kishimoto
Masaaki Ito
Kazuhiro Kaneko
Mizuo Maeda
Kohei Soga
spellingShingle Tamotsu Zako
Hiroshi Hyodo
Kosuke Tsuji
Kimikazu Tokuzen
Hidehiro Kishimoto
Masaaki Ito
Kazuhiro Kaneko
Mizuo Maeda
Kohei Soga
Development of Near Infrared-Fluorescent Nanophosphors and Applications for Cancer Diagnosis and Therapy
Journal of Nanomaterials
author_facet Tamotsu Zako
Hiroshi Hyodo
Kosuke Tsuji
Kimikazu Tokuzen
Hidehiro Kishimoto
Masaaki Ito
Kazuhiro Kaneko
Mizuo Maeda
Kohei Soga
author_sort Tamotsu Zako
title Development of Near Infrared-Fluorescent Nanophosphors and Applications for Cancer Diagnosis and Therapy
title_short Development of Near Infrared-Fluorescent Nanophosphors and Applications for Cancer Diagnosis and Therapy
title_full Development of Near Infrared-Fluorescent Nanophosphors and Applications for Cancer Diagnosis and Therapy
title_fullStr Development of Near Infrared-Fluorescent Nanophosphors and Applications for Cancer Diagnosis and Therapy
title_full_unstemmed Development of Near Infrared-Fluorescent Nanophosphors and Applications for Cancer Diagnosis and Therapy
title_sort development of near infrared-fluorescent nanophosphors and applications for cancer diagnosis and therapy
publisher Hindawi Limited
series Journal of Nanomaterials
issn 1687-4110
1687-4129
publishDate 2010-01-01
description The use of near infrared (NIR) light for biomedical photonics in the wavelength region between 800 and 2000 nm, which is called “biological window”, has received particular attention since water and biological tissues have minimal optical loss due to scattering and absorption as well as autofluorescence in this region. Recent development of InGaAs CCD enables observations in this wavelength region. In the present paper, we report development of Yb and Er-doped yttrium oxide nanoparticles (Y2O3:YbEr-NP) which show strong NIR emission under NIR excitation (NIR-NIR emission). We also demonstrate that NIR emission can be observed through swine colon wall. Based on these results, we propose a possible application of Y2O3:YbEr-NP for cancer diagnosis and therapy using NIR-NIR imaging system. Our results also suggest potential applications of Y2O3:YbEr-NP for noninvasive detection of various diseases.
url http://dx.doi.org/10.1155/2010/491471
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AT hiroshihyodo developmentofnearinfraredfluorescentnanophosphorsandapplicationsforcancerdiagnosisandtherapy
AT kosuketsuji developmentofnearinfraredfluorescentnanophosphorsandapplicationsforcancerdiagnosisandtherapy
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