Cytokine Expression in Canine Lymphoma, Osteosarcoma, Mammary Gland Tumour and Melanoma: Comparative Aspects

• Main Authors: Sergio Erdal Irac, Annika Oksa, Karen Jackson, Aaron Herndon, Rachel Allavena, Chiara Palmieri
• Format: Article
• Language: English
• Published: MDPI AG 2019-04-01
• Series: Veterinary Sciences
• Subjects: osteosarcoma; melanoma; lymphoma; mammary gland tumours; cytokines
• Online Access: https://www.mdpi.com/2306-7381/6/2/37

Cytokines released in the tumour microenvironment play a major role in cancer pathogenesis. In human cancers and corresponding animal models, cytokine expression contributes to tumour growth and progression, as well as regulation of the host anti-tumour response. The elucidation of the function and importance of cytokines in canine cancers is still in an early stage, although relevant data have been obtained in classical examples of comparative models of human cancers, such as osteosarcoma, melanoma, mammary tumour and lymphoma. A deeper understanding of the cytokine signature may advance diagnosis, prevention and treatment of canine cancers.