Plasma and Red Blood Cell PUFAs in Home Parenteral Nutrition Paediatric Patients—Effects of Lipid Emulsions
<i>Background</i>: Mixed lipid emulsions (LE) containing fish oil present several advantages compared to the sole soybean oil LE, but little is known about the safety of essential fatty acids (EFA) profile in paediatric patients on long-term Parenteral Nutrition (PN). <i>Aim of the...
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MDPI AG
2020-12-01
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Series: | Nutrients |
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Online Access: | https://www.mdpi.com/2072-6643/12/12/3748 |
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doaj-b99cf83c10d247b3bb81450ddb2e74e7 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antonella Lezo Valentina D’Onofrio Maria Paola Puccinelli Teresa Capriati Antonella De Francesco Simona Bo Paola Massarenti Paolo Gandullia Marta Marin Liliana Derevlean Letizia Baldini Filomena Longo Antonella Diamanti |
spellingShingle |
Antonella Lezo Valentina D’Onofrio Maria Paola Puccinelli Teresa Capriati Antonella De Francesco Simona Bo Paola Massarenti Paolo Gandullia Marta Marin Liliana Derevlean Letizia Baldini Filomena Longo Antonella Diamanti Plasma and Red Blood Cell PUFAs in Home Parenteral Nutrition Paediatric Patients—Effects of Lipid Emulsions Nutrients parenteral nutrition PUFAs composite lipid emulsions fatty acids deficiency |
author_facet |
Antonella Lezo Valentina D’Onofrio Maria Paola Puccinelli Teresa Capriati Antonella De Francesco Simona Bo Paola Massarenti Paolo Gandullia Marta Marin Liliana Derevlean Letizia Baldini Filomena Longo Antonella Diamanti |
author_sort |
Antonella Lezo |
title |
Plasma and Red Blood Cell PUFAs in Home Parenteral Nutrition Paediatric Patients—Effects of Lipid Emulsions |
title_short |
Plasma and Red Blood Cell PUFAs in Home Parenteral Nutrition Paediatric Patients—Effects of Lipid Emulsions |
title_full |
Plasma and Red Blood Cell PUFAs in Home Parenteral Nutrition Paediatric Patients—Effects of Lipid Emulsions |
title_fullStr |
Plasma and Red Blood Cell PUFAs in Home Parenteral Nutrition Paediatric Patients—Effects of Lipid Emulsions |
title_full_unstemmed |
Plasma and Red Blood Cell PUFAs in Home Parenteral Nutrition Paediatric Patients—Effects of Lipid Emulsions |
title_sort |
plasma and red blood cell pufas in home parenteral nutrition paediatric patients—effects of lipid emulsions |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-12-01 |
description |
<i>Background</i>: Mixed lipid emulsions (LE) containing fish oil present several advantages compared to the sole soybean oil LE, but little is known about the safety of essential fatty acids (EFA) profile in paediatric patients on long-term Parenteral Nutrition (PN). <i>Aim of the study</i>: to assess glycerophosfolipid polyunsaturated fatty acids (PUFA) levels on plasma and red blood cell (RBC) membrane of children on long term PN with composite LE containing fish oil (SMOF), and to compare it with a group receiving olive oil LE (Clinoleic<sup>®</sup>) and to the reference range for age, previously determined on a group of healthy children. <i>Results</i>: A total of 38 patients were enrolled, median age 5.56 (0.9–21.86) years, 15 receiving Clinoleic<sup>®</sup>, 23 receiving SMOF. Patients on SMOF showed significantly higher levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lower levels of arachidonic acid (ARA) and Mead acid (MEAD)/ARA ratio in plasma and RBC compared with patients on Clinoleic<sup>®</sup> and with healthy children. Triene:tetraene (T:T) ratio of both groups of patients did not differ from that of healthy children-median plasma (MEAD/ARA: 0.01, interquartile rage (IQR) 0.01, <i>p</i> = 0.61 and 0.02, IQR 0.02, <i>p</i> = 0.6 in SMOF and Clinoleic<sup>®</sup> patients, respectively), and was considerably lower than Holman index (>0.21). SMOF patients showed no statistically significant differences in growth parameters compared with Clinoleic<sup>®</sup> patients. Patients of both groups showed stiffness class F0-F1 of liver stiffness measure (LSM) 5.6 (IQR 0.85) in SMOF patients and 5.3 (IQR 0.90) in Clinoleic<sup>®</sup> patients, <i>p</i> = 0.58), indicating absence of liver fibrosis. <i>Conclusions</i>: Fatty acids, measured as concentrations (mg/L), revealed specific PUFA profile of PN patients and could be an accurate method to evaluate nutritional status and eventually to detect essential fatty acid deficiency (EFAD). SMOF patients showed significantly higher EPA, DHA and lower ARA concentrations compared to Clinoleic<sup>®</sup> patients. Both LEs showed similar hepatic evolution and growth. |
topic |
parenteral nutrition PUFAs composite lipid emulsions fatty acids deficiency |
url |
https://www.mdpi.com/2072-6643/12/12/3748 |
work_keys_str_mv |
AT antonellalezo plasmaandredbloodcellpufasinhomeparenteralnutritionpaediatricpatientseffectsoflipidemulsions AT valentinadonofrio plasmaandredbloodcellpufasinhomeparenteralnutritionpaediatricpatientseffectsoflipidemulsions AT mariapaolapuccinelli plasmaandredbloodcellpufasinhomeparenteralnutritionpaediatricpatientseffectsoflipidemulsions AT teresacapriati plasmaandredbloodcellpufasinhomeparenteralnutritionpaediatricpatientseffectsoflipidemulsions AT antonelladefrancesco plasmaandredbloodcellpufasinhomeparenteralnutritionpaediatricpatientseffectsoflipidemulsions AT simonabo plasmaandredbloodcellpufasinhomeparenteralnutritionpaediatricpatientseffectsoflipidemulsions AT paolamassarenti plasmaandredbloodcellpufasinhomeparenteralnutritionpaediatricpatientseffectsoflipidemulsions AT paologandullia plasmaandredbloodcellpufasinhomeparenteralnutritionpaediatricpatientseffectsoflipidemulsions AT martamarin plasmaandredbloodcellpufasinhomeparenteralnutritionpaediatricpatientseffectsoflipidemulsions AT lilianaderevlean plasmaandredbloodcellpufasinhomeparenteralnutritionpaediatricpatientseffectsoflipidemulsions AT letiziabaldini plasmaandredbloodcellpufasinhomeparenteralnutritionpaediatricpatientseffectsoflipidemulsions AT filomenalongo plasmaandredbloodcellpufasinhomeparenteralnutritionpaediatricpatientseffectsoflipidemulsions AT antonelladiamanti plasmaandredbloodcellpufasinhomeparenteralnutritionpaediatricpatientseffectsoflipidemulsions |
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doaj-b99cf83c10d247b3bb81450ddb2e74e72020-12-06T00:02:20ZengMDPI AGNutrients2072-66432020-12-01123748374810.3390/nu12123748Plasma and Red Blood Cell PUFAs in Home Parenteral Nutrition Paediatric Patients—Effects of Lipid EmulsionsAntonella Lezo0Valentina D’Onofrio1Maria Paola Puccinelli2Teresa Capriati3Antonella De Francesco4Simona Bo5Paola Massarenti6Paolo Gandullia7Marta Marin8Liliana Derevlean9Letizia Baldini10Filomena Longo11Antonella Diamanti12Dietetics and Clinical Nutrition Unit, Children’s Hospital Regina Margherita, AOU Città della Salute e della Scienza di Torino, 10126 Torino, ItalyDepartment of Medical Sciences, Faculty of Medicine, Università degli Studi di Torino, 10126 Torino, ItalyLaboratory of Clinical Biochemistry “Baldi e Riberi”, Metabolic Diseases Unit, AOU Città della Salute e della Scienza di Torino, 10126 Torino, ItalyArtificial Nutrition Division, Ospedale Bambino Gesù, 00165 Roma, ItalyDietetics and Clinical Nutrition Department, AOU Città della Salute e della Scienza, 10126 Torino, ItalyDepartment of Medical Sciences, Faculty of Medicine, Università degli Studi di Torino, 10126 Torino, ItalyLaboratory of Clinical Biochemistry “Baldi e Riberi”, Metabolic Diseases Unit, AOU Città della Salute e della Scienza di Torino, 10126 Torino, ItalyPediatric Gastroenterology Department, IRCCS Giannina Gaslini, 16147 Genoa, ItalyPediatric Gastroenterology Department, IRCCS Giannina Gaslini, 16147 Genoa, ItalyLaboratory of Clinical Biochemistry “Baldi e Riberi”, Metabolic Diseases Unit, AOU Città della Salute e della Scienza di Torino, 10126 Torino, ItalyPost-graduate School of Pediatrics, Università degli Studi di Torino, 10126 Torino, ItalyPediatric Department, Microcythemia Center, AOU San Luigi Gonzaga, Orbassano, 10043 Torino, ItalyArtificial Nutrition Division, Ospedale Bambino Gesù, 00165 Roma, Italy<i>Background</i>: Mixed lipid emulsions (LE) containing fish oil present several advantages compared to the sole soybean oil LE, but little is known about the safety of essential fatty acids (EFA) profile in paediatric patients on long-term Parenteral Nutrition (PN). <i>Aim of the study</i>: to assess glycerophosfolipid polyunsaturated fatty acids (PUFA) levels on plasma and red blood cell (RBC) membrane of children on long term PN with composite LE containing fish oil (SMOF), and to compare it with a group receiving olive oil LE (Clinoleic<sup>®</sup>) and to the reference range for age, previously determined on a group of healthy children. <i>Results</i>: A total of 38 patients were enrolled, median age 5.56 (0.9–21.86) years, 15 receiving Clinoleic<sup>®</sup>, 23 receiving SMOF. Patients on SMOF showed significantly higher levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lower levels of arachidonic acid (ARA) and Mead acid (MEAD)/ARA ratio in plasma and RBC compared with patients on Clinoleic<sup>®</sup> and with healthy children. Triene:tetraene (T:T) ratio of both groups of patients did not differ from that of healthy children-median plasma (MEAD/ARA: 0.01, interquartile rage (IQR) 0.01, <i>p</i> = 0.61 and 0.02, IQR 0.02, <i>p</i> = 0.6 in SMOF and Clinoleic<sup>®</sup> patients, respectively), and was considerably lower than Holman index (>0.21). SMOF patients showed no statistically significant differences in growth parameters compared with Clinoleic<sup>®</sup> patients. Patients of both groups showed stiffness class F0-F1 of liver stiffness measure (LSM) 5.6 (IQR 0.85) in SMOF patients and 5.3 (IQR 0.90) in Clinoleic<sup>®</sup> patients, <i>p</i> = 0.58), indicating absence of liver fibrosis. <i>Conclusions</i>: Fatty acids, measured as concentrations (mg/L), revealed specific PUFA profile of PN patients and could be an accurate method to evaluate nutritional status and eventually to detect essential fatty acid deficiency (EFAD). SMOF patients showed significantly higher EPA, DHA and lower ARA concentrations compared to Clinoleic<sup>®</sup> patients. Both LEs showed similar hepatic evolution and growth.https://www.mdpi.com/2072-6643/12/12/3748parenteral nutritionPUFAscomposite lipid emulsionsfatty acids deficiency |