Dehydrocostus Lactone Attenuates the Senescence of Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration via Inhibition of STING-TBK1/NF-κB and MAPK Signaling

Dehydrocostus Lactone Attenuates the Senescence of Nucleus Pulposus Cells and Ameliorates Intervertebral Disc Degeneration via Inhibition of STING-TBK1/NF-κB and MAPK Signaling

The progression of intervertebral disc degeneration (IDD) is multifactorial with the senescence of nucleus pulposus (NP) cells and closely related to inflammation in NP cells. Dehydrocostus lactone (DHE) is a natural sesquiterpene lactone isolated from medicinal plants that has anti-inflammatory pro...

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Bibliographic Details
Main Authors:	Zhiqian Chen, Xiao Yang, Yifan Zhou, Zhihao Liang, Chen Chen, Chen Han, Xiankun Cao, Wenxin He, Kai Zhang, An Qin, Tangjun Zhou, Jie Zhao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-04-01
Series:	Frontiers in Pharmacology
Subjects:	intervertebral disc degeneration inflammation dehydrocostus lactone senescence nucleus pulposus cells
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.641098/full

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