Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer

Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer

Background: Sulforaphane (SFN), an activator of nuclear factor erythroid-2 related factor 2 (Nrf2), is a promising chemopreventive agent which is undergoing clinical trial for several diseases. Studies have indicated that there is gain of Nrf2 function in lung cancer and other solid tumors because o...

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Bibliographic Details
Main Authors: Ponvijay Kombairaju, Jinfang Ma, Rajesh K Thimmulappa, G Shengbin Yan, Edward Gabrielson, Anju Singh, Shyam Biswal
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2012-01-01
Series:Journal of Carcinogenesis
Subjects:
EGFR
Keap1
K-ras
lung cancer
Nrf2
sulforaphane
Online Access:http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2012;volume=11;issue=1;spage=8;epage=8;aulast=Kombairaju

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