RISK FACTORS OF COGNITIVE IMPAIRMENT IN PARKINSON’S DISEASE AND DISCIRCULATORY ENCEPHALOPATHY

• Main Authors: S. B. Sayutina, V. V. Shprakh, N. Y. Rozhkova
• Format: Article
• Language: Russian
• Published: Scientific Сentre for Family Health and Human Reproduction Problems 2017-04-01
• Series: Acta Biomedica Scientifica
• Subjects: parkinson's disease; discirculatory encephalopathy; cognitive impairment; risk factors
• Online Access: https://www.actabiomedica.ru/jour/article/view/616
• ISSN: 2541-9420; 2587-9596

The aim of the study was to examine the state of cognitive functions in patients with Parkinson's disease combined with the dyscirculatory encephalopathy and identify their risk factors for cognitive impairment. The results of the study showed that the frequency of cognitive impairment in patients with Parkinson's disease combined with the dyscirculatory encephalopathy was 90.3 %, Parkinson's disease without brain vascular disease - 28.6 %. Patients with concomitant cerebrovascular disease had more severe frontal deficit (mean score on the FAB in the main group -14.86 ± 2.18, in the control -16.93 ± 2.21; p < 0.0001), which manifested itself in the form of difficulty when performing tests for dynamic movements, simple and complicated reactions of choice, had the worst performance of speech and general mental activity, attention. In order to assess the relationship of certain clinical, social and biological factors with indicators of cognitive functions we conducted Spearman rank correlation analysis. Risk factors for the development of cognitive impairment of Parkinson's disease combined with vascular encephalopathy were age of patients, severity of motor impairment, duration and severity of hypertension, coronary heart disease, and the presence of acute cardiovascular events in history.