Folding and assembly of large macromolecular complexes monitored by hydrogen-deuterium exchange and mass spectrometry

<p>Abstract</p> <p>Recent advances in protein mass spectrometry (MS) have enabled determinations of hydrogen deuterium exchange (HDX) in large macromolecular complexes. HDX-MS became a valuable tool to follow protein folding, assembly and aggregation. The methodology has a wide ran...

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Bibliographic Details
Main Authors: Tuma Roman, Suchanova Bohumila
Format: Article
Language:English
Published: BMC 2008-04-01
Series:Microbial Cell Factories
Online Access:http://www.microbialcellfactories.com/content/7/1/12

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