The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape Programs

The C-X-C Motif Chemokine Ligand 1 Sustains Breast Cancer Stem Cell Self-Renewal and Promotes Tumor Progression and Immune Escape Programs

Breast cancer (BC) mortality is mainly due to metastatic disease, which is primarily driven by cancer stem cells (CSC). The chemokine C-X-C motif ligand-1 (CXCL1) is involved in BC metastasis, but the question of whether it regulates breast cancer stem cell (BCSC) behavior is yet to be explored. Her...

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Bibliographic Details
Main Authors: Stefania Livia Ciummo, Luigi D’Antonio, Carlo Sorrentino, Cristiano Fieni, Paola Lanuti, Giorgio Stassi, Matilde Todaro, Emma Di Carlo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
breast cancer stem cells
chemokines
CXCL1
tumor microenvironment
immunity genes
triple-negative breast cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.689286/full

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