Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats
Angiotensin converting enzyme inhibitors and propofol both exert hypotensive action and may affect hemostasis. We investigated the influence of quinapril and propofol on hemodynamics and hemostasis in renal-hypertensive rats with induced arterial thrombosis. Two-kidney, one clip hypertensive rats we...
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Series: | Journal of the Renin-Angiotensin-Aldosterone System |
Online Access: | https://doi.org/10.1177/1470320316647239 |
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doaj-b9c3044d190c49e893331b83f26bdbeb2021-05-02T14:43:58ZengHindawi - SAGE PublishingJournal of the Renin-Angiotensin-Aldosterone System1752-89762016-05-011710.1177/1470320316647239Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive ratsMarzena Wojewodzka-Zelezniakowicz0Wioleta Kisiel1Karol Kramkowski2Anna Gromotowicz-Poplawska3Agnieszka Zakrzeska4Adrian Stankiewicz5Patrycjusz Kolodziejczyk6Janusz Szemraj7Jerzy Robert Ladny8Ewa Chabielska9Department of Emergency and Disaster Medicine, Medical University of Bialystok, PolandDepartment of Biopharmacy, Medical University of Bialystok, PolandDepartment of Biopharmacy, Medical University of Bialystok, PolandDepartment of Biopharmacy, Medical University of Bialystok, PolandDepartment of Biopharmacy, Medical University of Bialystok, PolandDepartment of Biopharmacy, Medical University of Bialystok, PolandDepartment of Biopharmacy, Medical University of Bialystok, PolandDepartment of Medical Biochemistry, Medical University of Lodz, PolandDepartment of Emergency and Disaster Medicine, Medical University of Bialystok, PolandDepartment of Biopharmacy, Medical University of Bialystok, PolandAngiotensin converting enzyme inhibitors and propofol both exert hypotensive action and may affect hemostasis. We investigated the influence of quinapril and propofol on hemodynamics and hemostasis in renal-hypertensive rats with induced arterial thrombosis. Two-kidney, one clip hypertensive rats were treated with quinapril (3.0 mg/kg for 10 days), and then received propofol infusion (15 mg/kg/h) during ongoing arterial thrombosis. The hemodynamic and hemostatic parameters were assayed. Quinapril exerted a hypotensive effect increasing after propofol infusion. Quinapril showed an antithrombotic effect with the platelet adhesion reduction, fibrinolysis enhancement and oxidative stress reduction. Propofol did not influence thrombosis; however, it inhibited fibrinolysis and showed prooxidative action. The effect of propofol on fibrinolysis and oxidative stress was significantly lower in quinapril-pretreated rats. Mortality was increased among rats treated with both drugs together. Our study demonstrates that pretreatment with quinapril reduced the adverse effects of propofol on hemostasis. Unfortunately, co-administration of both drugs potentiated hypotension in rats, which corresponds to higher mortality.https://doi.org/10.1177/1470320316647239 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marzena Wojewodzka-Zelezniakowicz Wioleta Kisiel Karol Kramkowski Anna Gromotowicz-Poplawska Agnieszka Zakrzeska Adrian Stankiewicz Patrycjusz Kolodziejczyk Janusz Szemraj Jerzy Robert Ladny Ewa Chabielska |
spellingShingle |
Marzena Wojewodzka-Zelezniakowicz Wioleta Kisiel Karol Kramkowski Anna Gromotowicz-Poplawska Agnieszka Zakrzeska Adrian Stankiewicz Patrycjusz Kolodziejczyk Janusz Szemraj Jerzy Robert Ladny Ewa Chabielska Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats Journal of the Renin-Angiotensin-Aldosterone System |
author_facet |
Marzena Wojewodzka-Zelezniakowicz Wioleta Kisiel Karol Kramkowski Anna Gromotowicz-Poplawska Agnieszka Zakrzeska Adrian Stankiewicz Patrycjusz Kolodziejczyk Janusz Szemraj Jerzy Robert Ladny Ewa Chabielska |
author_sort |
Marzena Wojewodzka-Zelezniakowicz |
title |
Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats |
title_short |
Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats |
title_full |
Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats |
title_fullStr |
Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats |
title_full_unstemmed |
Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats |
title_sort |
quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats |
publisher |
Hindawi - SAGE Publishing |
series |
Journal of the Renin-Angiotensin-Aldosterone System |
issn |
1752-8976 |
publishDate |
2016-05-01 |
description |
Angiotensin converting enzyme inhibitors and propofol both exert hypotensive action and may affect hemostasis. We investigated the influence of quinapril and propofol on hemodynamics and hemostasis in renal-hypertensive rats with induced arterial thrombosis. Two-kidney, one clip hypertensive rats were treated with quinapril (3.0 mg/kg for 10 days), and then received propofol infusion (15 mg/kg/h) during ongoing arterial thrombosis. The hemodynamic and hemostatic parameters were assayed. Quinapril exerted a hypotensive effect increasing after propofol infusion. Quinapril showed an antithrombotic effect with the platelet adhesion reduction, fibrinolysis enhancement and oxidative stress reduction. Propofol did not influence thrombosis; however, it inhibited fibrinolysis and showed prooxidative action. The effect of propofol on fibrinolysis and oxidative stress was significantly lower in quinapril-pretreated rats. Mortality was increased among rats treated with both drugs together. Our study demonstrates that pretreatment with quinapril reduced the adverse effects of propofol on hemostasis. Unfortunately, co-administration of both drugs potentiated hypotension in rats, which corresponds to higher mortality. |
url |
https://doi.org/10.1177/1470320316647239 |
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