Modulation of <i>PTPN2/22</i> Function by Spermidine in CRISPR-Cas9-Edited T-Cells Associated with Crohn’s Disease and Rheumatoid Arthritis

Modulation of <i>PTPN2/22</i> Function by Spermidine in CRISPR-Cas9-Edited T-Cells Associated with Crohn’s Disease and Rheumatoid Arthritis

Crohn’s Disease (CD) and Rheumatoid Arthritis (RA) share some single nucleotide polymorphisms (SNPs) in protein tyrosine phosphatase non-receptor types 2 and 22 (<i>PTPN2/22</i>). Recently, we reported that clinical samples from CD and RA patients associated with <i>PTPN2:rs478582&...

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Bibliographic Details
Main Authors: Ameera M. Shaw, Ahmad Qasem, Saleh A. Naser
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
Crohn’s Disease
Rheumatoid Arthritis
PTPN2
PTPN22
spermidine
polyamines
Online Access:https://www.mdpi.com/1422-0067/22/16/8883

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