Expression Pattern of Axin2 During Chicken Development.
Canonical Wnt-signalling is well understood and has been extensively described in many developmental processes. The regulation of this signalling pathway is of outstanding relevance for proper development of the vertebrate and invertebrate embryo. Axin2 provides a negative-feedback-loop in the canon...
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doaj-b9c8a7d40f0349f0bbc28fa0037a5a7a2020-11-24T22:03:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01119e016361010.1371/journal.pone.0163610Expression Pattern of Axin2 During Chicken Development.Gesa EckeiMarion BöingBeate Brand-SaberiGabriela Morosan-PuopoloCanonical Wnt-signalling is well understood and has been extensively described in many developmental processes. The regulation of this signalling pathway is of outstanding relevance for proper development of the vertebrate and invertebrate embryo. Axin2 provides a negative-feedback-loop in the canonical Wnt-pathway, being a target gene and a negative regulator. Here we provide a detailed analysis of the expression pattern in the development of the chicken embryo. By performing in-situ hybridization on chicken embryos from stage HH 04+ to HH 32 we detected a temporally and spatially restricted dynamic expression of Axin2. In particular, data about the expression of Axin2 mRNA in early embryogenesis, somites, neural tube, limbs, kidney and eyes was obtained.http://europepmc.org/articles/PMC5040342?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gesa Eckei Marion Böing Beate Brand-Saberi Gabriela Morosan-Puopolo |
spellingShingle |
Gesa Eckei Marion Böing Beate Brand-Saberi Gabriela Morosan-Puopolo Expression Pattern of Axin2 During Chicken Development. PLoS ONE |
author_facet |
Gesa Eckei Marion Böing Beate Brand-Saberi Gabriela Morosan-Puopolo |
author_sort |
Gesa Eckei |
title |
Expression Pattern of Axin2 During Chicken Development. |
title_short |
Expression Pattern of Axin2 During Chicken Development. |
title_full |
Expression Pattern of Axin2 During Chicken Development. |
title_fullStr |
Expression Pattern of Axin2 During Chicken Development. |
title_full_unstemmed |
Expression Pattern of Axin2 During Chicken Development. |
title_sort |
expression pattern of axin2 during chicken development. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
Canonical Wnt-signalling is well understood and has been extensively described in many developmental processes. The regulation of this signalling pathway is of outstanding relevance for proper development of the vertebrate and invertebrate embryo. Axin2 provides a negative-feedback-loop in the canonical Wnt-pathway, being a target gene and a negative regulator. Here we provide a detailed analysis of the expression pattern in the development of the chicken embryo. By performing in-situ hybridization on chicken embryos from stage HH 04+ to HH 32 we detected a temporally and spatially restricted dynamic expression of Axin2. In particular, data about the expression of Axin2 mRNA in early embryogenesis, somites, neural tube, limbs, kidney and eyes was obtained. |
url |
http://europepmc.org/articles/PMC5040342?pdf=render |
work_keys_str_mv |
AT gesaeckei expressionpatternofaxin2duringchickendevelopment AT marionboing expressionpatternofaxin2duringchickendevelopment AT beatebrandsaberi expressionpatternofaxin2duringchickendevelopment AT gabrielamorosanpuopolo expressionpatternofaxin2duringchickendevelopment |
_version_ |
1725832031358681088 |