Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy

Qiangying Yi,1 Jin Ma,1 Ke Kang,1 Zhongwei Gu1,2 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 2College of Materials Science and Engineering, Nanjing Tech University, Nanjing, P.R. China Introduction: Increasing demands in precise control over delivery and fu...

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Main Authors: Yi Q, Ma J, Kang K, Gu Z
Format: Article
Language:English
Published: Dove Medical Press 2018-01-01
Series:International Journal of Nanomedicine
Subjects:
Online Access:https://www.dovepress.com/bioreducible-nanocapsules-for-folic-acid-assisted-targeting-and-effect-peer-reviewed-article-IJN
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spelling doaj-b9cc65e87b61452db98ae418c4b01a112020-11-24T22:57:04ZengDove Medical PressInternational Journal of Nanomedicine1178-20132018-01-01Volume 1365366736609Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapyYi QMa JKang KGu ZQiangying Yi,1 Jin Ma,1 Ke Kang,1 Zhongwei Gu1,2 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 2College of Materials Science and Engineering, Nanjing Tech University, Nanjing, P.R. China Introduction: Increasing demands in precise control over delivery and functionalization of therapeutic agents for tumor-specific chemotherapy have led to a rapid development in nanocarriers. Herein, we report a nanocapsule (NC) system for tumor-oriented drug delivery and effective tumor therapy.Materials and methods: Functionalized hyaluronan is utilized to build up the NC shells, in which bioreduction cleavable sites, targeting ligand folic acid (FA), and zwitterionic tentacles are integrated.Results: The hollow NCs obtained (~50 nm in diameter) showed well-defined spherical shell structures with a shell thickness of ~8 nm. These specially designed NCs (doxorubicin [DOX]/FA-Z-NCs) with high drug encapsulation content exhibited good biocompatibility in vitro and fast intracellular drug release behavior mediated by intracellular glutathione.Conclusion: Cellular uptake tests demonstrated rapid uptake of these functionalized NCs and effective escape from endosomes. Antitumor efficacy of the DOX/FA-Z-NCs was confirmed by the significant tumor growth inhibition effect as well as greatly reduced side effects, in contrast with those of the free drug DOX hydrochloride. Keywords: drug delivery, active targeting, zwitterionic poly(carboxybetaine methacrylate), doxorubicinhttps://www.dovepress.com/bioreducible-nanocapsules-for-folic-acid-assisted-targeting-and-effect-peer-reviewed-article-IJNdrug deliveryactive targetingzwitterionic poly(carboxybetaine methacrylate)doxorubicin
collection DOAJ
language English
format Article
sources DOAJ
author Yi Q
Ma J
Kang K
Gu Z
spellingShingle Yi Q
Ma J
Kang K
Gu Z
Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
International Journal of Nanomedicine
drug delivery
active targeting
zwitterionic poly(carboxybetaine methacrylate)
doxorubicin
author_facet Yi Q
Ma J
Kang K
Gu Z
author_sort Yi Q
title Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
title_short Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
title_full Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
title_fullStr Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
title_full_unstemmed Bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
title_sort bioreducible nanocapsules for folic acid-assisted targeting and effective tumor-specific chemotherapy
publisher Dove Medical Press
series International Journal of Nanomedicine
issn 1178-2013
publishDate 2018-01-01
description Qiangying Yi,1 Jin Ma,1 Ke Kang,1 Zhongwei Gu1,2 1National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 2College of Materials Science and Engineering, Nanjing Tech University, Nanjing, P.R. China Introduction: Increasing demands in precise control over delivery and functionalization of therapeutic agents for tumor-specific chemotherapy have led to a rapid development in nanocarriers. Herein, we report a nanocapsule (NC) system for tumor-oriented drug delivery and effective tumor therapy.Materials and methods: Functionalized hyaluronan is utilized to build up the NC shells, in which bioreduction cleavable sites, targeting ligand folic acid (FA), and zwitterionic tentacles are integrated.Results: The hollow NCs obtained (~50 nm in diameter) showed well-defined spherical shell structures with a shell thickness of ~8 nm. These specially designed NCs (doxorubicin [DOX]/FA-Z-NCs) with high drug encapsulation content exhibited good biocompatibility in vitro and fast intracellular drug release behavior mediated by intracellular glutathione.Conclusion: Cellular uptake tests demonstrated rapid uptake of these functionalized NCs and effective escape from endosomes. Antitumor efficacy of the DOX/FA-Z-NCs was confirmed by the significant tumor growth inhibition effect as well as greatly reduced side effects, in contrast with those of the free drug DOX hydrochloride. Keywords: drug delivery, active targeting, zwitterionic poly(carboxybetaine methacrylate), doxorubicin
topic drug delivery
active targeting
zwitterionic poly(carboxybetaine methacrylate)
doxorubicin
url https://www.dovepress.com/bioreducible-nanocapsules-for-folic-acid-assisted-targeting-and-effect-peer-reviewed-article-IJN
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