Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project
Organophosphates and carbamates have been among the most commonly used insecticides, with both agricultural and residential uses. Previous studies have suggested associations of non-Hodgkin lymphoma (NHL) with some of these chemicals; however, many studies have been limited in their ability to evalu...
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Elsevier
2019-06-01
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Series: | Environment International |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412018321305 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stella Koutros Shelley A. Harris John J. Spinelli Aaron Blair John R. McLaughlin Shelia Hoar Zahm Sungduk Kim Paul S. Albert Linda Kachuri Manisha Pahwa Kenneth P. Cantor Dennis D. Weisenburger Punam Pahwa Larissa A. Pardo James A. Dosman Paul A. Demers Laura E. Beane Freeman |
spellingShingle |
Stella Koutros Shelley A. Harris John J. Spinelli Aaron Blair John R. McLaughlin Shelia Hoar Zahm Sungduk Kim Paul S. Albert Linda Kachuri Manisha Pahwa Kenneth P. Cantor Dennis D. Weisenburger Punam Pahwa Larissa A. Pardo James A. Dosman Paul A. Demers Laura E. Beane Freeman Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project Environment International |
author_facet |
Stella Koutros Shelley A. Harris John J. Spinelli Aaron Blair John R. McLaughlin Shelia Hoar Zahm Sungduk Kim Paul S. Albert Linda Kachuri Manisha Pahwa Kenneth P. Cantor Dennis D. Weisenburger Punam Pahwa Larissa A. Pardo James A. Dosman Paul A. Demers Laura E. Beane Freeman |
author_sort |
Stella Koutros |
title |
Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project |
title_short |
Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project |
title_full |
Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project |
title_fullStr |
Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project |
title_full_unstemmed |
Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project |
title_sort |
non-hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north american pooled project |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2019-06-01 |
description |
Organophosphates and carbamates have been among the most commonly used insecticides, with both agricultural and residential uses. Previous studies have suggested associations of non-Hodgkin lymphoma (NHL) with some of these chemicals; however, many studies have been limited in their ability to evaluate associations with lymphoma subtypes. We evaluated the use of eleven organophosphate and two carbamate insecticides in association with NHL in the North American Pooled Project, which includes data from case-control studies in the United States and Canada (1690 cases/5131 controls). We used unconditional logistic regression adjusting for potential confounders, including use of other pesticides, to estimate odds ratios (OR) and 95% confidence intervals (CI) for associations between these chemicals and NHL overall, and NHL subtypes, i.e., follicular (FL), diffuse large B-cell (DLBCL), small lymphocytic lymphoma (SLL) and others. Ever use of malathion was associated with increased risk of NHL overall (OR = 1.43; 95% CI: 1.14–1.81) compared with never users. Categories using tertiles of duration (<4 yrs., 4–12 yrs., and >12 yrs) also showed a significant exposure-response for increasing years of use of malathion and risk of NHL (OR<4vsUnex = 1.33 (0.88, 2.03), OR4-12vsUnex = 1.42 (1.02, 1.96), OR>12vsUnex = 1.55 (1.05, 2.28, p-trend < 0.01)). In addition, malathion use was statistically significantly associated with FL (OR = 1.58; 95% CI: 1.11–2.27) and DLBCL (OR = 1.61; 95% CI: 1.16–2.22) while there were no apparent associations with SLL or other subtypes, the p-value for heterogeneity across subtypes, however, was not significant. These results support previous studies suggesting an association between insecticide use and NHL overall, and provide new information on associations with NHL subtypes. |
url |
http://www.sciencedirect.com/science/article/pii/S0160412018321305 |
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doaj-b9db3f1488a1473fa6ed27635caf6e9b2020-11-25T00:44:54ZengElsevierEnvironment International0160-41202019-06-01127199205Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled projectStella Koutros0Shelley A. Harris1John J. Spinelli2Aaron Blair3John R. McLaughlin4Shelia Hoar Zahm5Sungduk Kim6Paul S. Albert7Linda Kachuri8Manisha Pahwa9Kenneth P. Cantor10Dennis D. Weisenburger11Punam Pahwa12Larissa A. Pardo13James A. Dosman14Paul A. Demers15Laura E. Beane Freeman16Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA; Corresponding author at: Division of Cancer Epidemiology and Genetics, Occupational and Environmental Epidemiology Branch, National Cancer Institute, 9609 Medical Center Dr., Room #6E616, MSC 9771, Bethesda, MD 20892, USA.Occupational Cancer Research Centre, Cancer Care Ontario, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada; Prevention and Cancer Control, Cancer Care Ontario, Toronto, CanadaPopulation Oncology, BC Cancer, Vancouver, Canada; School of Population and Public Health, University of British Columbia, Vancouver, CanadaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USADalla Lana School of Public Health, University of Toronto, Toronto, Canada; Public Health Ontario, Toronto, CanadaShelia Zahm Consulting, Hermon, ME, USADivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USADivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USADepartment of Epidemiology & Biostatistics, University of California San Francisco, San Francisco, CA, USAOccupational Cancer Research Centre, Cancer Care Ontario, Toronto, CanadaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USACity of Hope, Duarte, CA, USACanadian Centre for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, Canada; Community Health and Epidemiology, College of Medicine, University of Saskatchewan, Saskatoon, CanadaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USACanadian Centre for Health and Safety in Agriculture, University of Saskatchewan, Saskatoon, CanadaOccupational Cancer Research Centre, Cancer Care Ontario, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada; School of Population and Public Health, University of British Columbia, Vancouver, CanadaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USAOrganophosphates and carbamates have been among the most commonly used insecticides, with both agricultural and residential uses. Previous studies have suggested associations of non-Hodgkin lymphoma (NHL) with some of these chemicals; however, many studies have been limited in their ability to evaluate associations with lymphoma subtypes. We evaluated the use of eleven organophosphate and two carbamate insecticides in association with NHL in the North American Pooled Project, which includes data from case-control studies in the United States and Canada (1690 cases/5131 controls). We used unconditional logistic regression adjusting for potential confounders, including use of other pesticides, to estimate odds ratios (OR) and 95% confidence intervals (CI) for associations between these chemicals and NHL overall, and NHL subtypes, i.e., follicular (FL), diffuse large B-cell (DLBCL), small lymphocytic lymphoma (SLL) and others. Ever use of malathion was associated with increased risk of NHL overall (OR = 1.43; 95% CI: 1.14–1.81) compared with never users. Categories using tertiles of duration (<4 yrs., 4–12 yrs., and >12 yrs) also showed a significant exposure-response for increasing years of use of malathion and risk of NHL (OR<4vsUnex = 1.33 (0.88, 2.03), OR4-12vsUnex = 1.42 (1.02, 1.96), OR>12vsUnex = 1.55 (1.05, 2.28, p-trend < 0.01)). In addition, malathion use was statistically significantly associated with FL (OR = 1.58; 95% CI: 1.11–2.27) and DLBCL (OR = 1.61; 95% CI: 1.16–2.22) while there were no apparent associations with SLL or other subtypes, the p-value for heterogeneity across subtypes, however, was not significant. These results support previous studies suggesting an association between insecticide use and NHL overall, and provide new information on associations with NHL subtypes.http://www.sciencedirect.com/science/article/pii/S0160412018321305 |