Oral Corticosteroids in Asthma: A Review of Benefits and Risks

Oral Corticosteroids in Asthma: A Review of Benefits and Risks

Oral corticosteroids (OCS) play an integral role in the pharmacological management of asthma, as well as a number of other inflammatory and autoimmune disorders. However, although their broad spectrum of effect is beneficial in controlling inflammation, it can also lead to undesirable effects on oth...

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Main Authors: Robert Schellenberg, Jonathan D R Adachi, Dennis Bowie, Jacques Brown, Lyn Guenther, Tina Kader, Graham E Trope
Format: Article
Language:English
Published: Hindawi Limited 2007-01-01
Series:Canadian Respiratory Journal
Online Access:http://dx.doi.org/10.1155/2007/160691
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spelling doaj-b9e318af77e443be9b510c1f133c51c72021-07-02T03:56:04ZengHindawi LimitedCanadian Respiratory Journal1198-22412007-01-0114Suppl C1C7C10.1155/2007/160691Oral Corticosteroids in Asthma: A Review of Benefits and RisksRobert Schellenberg0Jonathan D R Adachi1Dennis Bowie2Jacques Brown3Lyn Guenther4Tina Kader5Graham E Trope6St Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, CanadaSt Joseph’s Healthcare, McMaster University, Hamilton, Ontario, CanadaQueen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, CanadaLaval University, Quebec City, Quebec, CanadaLondon Health Sciences Centre, University of Western Ontario, London, Ontario, CanadaJewish General Hospital, McGill University, Montreal, Quebec, CanadaUniversity Health Network, University of Toronto, Toronto, Ontario, CanadaOral corticosteroids (OCS) play an integral role in the pharmacological management of asthma, as well as a number of other inflammatory and autoimmune disorders. However, although their broad spectrum of effect is beneficial in controlling inflammation, it can also lead to undesirable effects on other cells, resulting in adverse effects. The purpose of the present review is to discuss the particular benefits of OCS and to outline the optimal role of these agents in the management of asthma, drawing on evidence-based medicine and current clinical practice guidelines. The mandate for the present review also covers an analysis of the risk:benefit ratio as it pertains to OCS use in asthma. The more common adverse effects will be discussed and weighed against the possible benefits.http://dx.doi.org/10.1155/2007/160691
collection DOAJ
language English
format Article
sources DOAJ
author Robert Schellenberg
Jonathan D R Adachi
Dennis Bowie
Jacques Brown
Lyn Guenther
Tina Kader
Graham E Trope
spellingShingle Robert Schellenberg
Jonathan D R Adachi
Dennis Bowie
Jacques Brown
Lyn Guenther
Tina Kader
Graham E Trope
Oral Corticosteroids in Asthma: A Review of Benefits and Risks
Canadian Respiratory Journal
author_facet Robert Schellenberg
Jonathan D R Adachi
Dennis Bowie
Jacques Brown
Lyn Guenther
Tina Kader
Graham E Trope
author_sort Robert Schellenberg
title Oral Corticosteroids in Asthma: A Review of Benefits and Risks
title_short Oral Corticosteroids in Asthma: A Review of Benefits and Risks
title_full Oral Corticosteroids in Asthma: A Review of Benefits and Risks
title_fullStr Oral Corticosteroids in Asthma: A Review of Benefits and Risks
title_full_unstemmed Oral Corticosteroids in Asthma: A Review of Benefits and Risks
title_sort oral corticosteroids in asthma: a review of benefits and risks
publisher Hindawi Limited
series Canadian Respiratory Journal
issn 1198-2241
publishDate 2007-01-01
description Oral corticosteroids (OCS) play an integral role in the pharmacological management of asthma, as well as a number of other inflammatory and autoimmune disorders. However, although their broad spectrum of effect is beneficial in controlling inflammation, it can also lead to undesirable effects on other cells, resulting in adverse effects. The purpose of the present review is to discuss the particular benefits of OCS and to outline the optimal role of these agents in the management of asthma, drawing on evidence-based medicine and current clinical practice guidelines. The mandate for the present review also covers an analysis of the risk:benefit ratio as it pertains to OCS use in asthma. The more common adverse effects will be discussed and weighed against the possible benefits.
url http://dx.doi.org/10.1155/2007/160691
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AT lynguenther oralcorticosteroidsinasthmaareviewofbenefitsandrisks
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