Review of Biological Network Data and Its Applications

• Main Authors: Donghyeon Yu, MinSoo Kim, Guanghua Xiao, Tae Hyun Hwang
• Format: Article
• Language: English
• Published: Korea Genome Organization 2013-12-01
• Series: Genomics & Informatics
• Subjects: biological network; disease gene prioritization; gene regulatory networks; genome-wide association study; protein function prediction; protein-protein interaction
• Online Access: http://genominfo.org/upload/pdf/gni-11-200.pdf
• ISSN: 1598-866X; 2234-0742

Studying biological networks, such as protein-protein interactions, is key to understanding complex biological activities. Various types of large-scale biological datasets have been collected and analyzed with high-throughput technologies, including DNA microarray, next-generation sequencing, and the two-hybrid screening system, for this purpose. In this review, we focus on network-based approaches that help in understanding biological systems and identifying biological functions. Accordingly, this paper covers two major topics in network biology: reconstruction of gene regulatory networks and network-based applications, including protein function prediction, disease gene prioritization, and network-based genome-wide association study.