The sensitivity to change of the cluster headache quality of life scale assessed before and after deep brain stimulation of the ventral tegmental area

Abstract Background Cluster headache (CH) is a trigeminal autonomic cephalalgia (TAC) characterized by a highly disabling headache that negatively impacts quality of life and causes limitations in daily functioning as well as social functioning and family life. Since specific measures to assess the...

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Main Authors: Davide Cappon, Agata Ryterska, Harith Akram, Susie Lagrata, Sanjay Cheema, Jonathan Hyam, Ludvic Zrinzo, Manjit Matharu, Marjan Jahanshahi
Format: Article
Language:English
Published: BMC 2021-06-01
Series:The Journal of Headache and Pain
Subjects:
Online Access:https://doi.org/10.1186/s10194-021-01251-5
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language English
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author Davide Cappon
Agata Ryterska
Harith Akram
Susie Lagrata
Sanjay Cheema
Jonathan Hyam
Ludvic Zrinzo
Manjit Matharu
Marjan Jahanshahi
spellingShingle Davide Cappon
Agata Ryterska
Harith Akram
Susie Lagrata
Sanjay Cheema
Jonathan Hyam
Ludvic Zrinzo
Manjit Matharu
Marjan Jahanshahi
The sensitivity to change of the cluster headache quality of life scale assessed before and after deep brain stimulation of the ventral tegmental area
The Journal of Headache and Pain
Cluster headache
Trigeminal autonomic cephalalgias
Quality of life scale
Deep brain stimulation
author_facet Davide Cappon
Agata Ryterska
Harith Akram
Susie Lagrata
Sanjay Cheema
Jonathan Hyam
Ludvic Zrinzo
Manjit Matharu
Marjan Jahanshahi
author_sort Davide Cappon
title The sensitivity to change of the cluster headache quality of life scale assessed before and after deep brain stimulation of the ventral tegmental area
title_short The sensitivity to change of the cluster headache quality of life scale assessed before and after deep brain stimulation of the ventral tegmental area
title_full The sensitivity to change of the cluster headache quality of life scale assessed before and after deep brain stimulation of the ventral tegmental area
title_fullStr The sensitivity to change of the cluster headache quality of life scale assessed before and after deep brain stimulation of the ventral tegmental area
title_full_unstemmed The sensitivity to change of the cluster headache quality of life scale assessed before and after deep brain stimulation of the ventral tegmental area
title_sort sensitivity to change of the cluster headache quality of life scale assessed before and after deep brain stimulation of the ventral tegmental area
publisher BMC
series The Journal of Headache and Pain
issn 1129-2369
1129-2377
publishDate 2021-06-01
description Abstract Background Cluster headache (CH) is a trigeminal autonomic cephalalgia (TAC) characterized by a highly disabling headache that negatively impacts quality of life and causes limitations in daily functioning as well as social functioning and family life. Since specific measures to assess the quality of life (QoL) in TACs are lacking, we recently developed and validated the cluster headache quality of life scale (CH-QoL). The sensitivity of CH-QoL to change after a medical intervention has not been evaluated yet. Methods This study aimed to test the sensitivity to change of the CH-QoL in CH. Specifically we aimed to (i) assess the sensitivity of CH-QoL to change before and following deep brain stimulation of the ventral tegmental area (VTA-DBS), (ii) evaluate the relationship of changes on CH-QoL with changes in other generic measures of quality of life, as well as indices of mood and pain. Ten consecutive CH patients completed the CH-QoL and underwent neuropsychological assessment before and after VTA-DBS. The patients were evaluated on headache frequency, severity, and load (HAL) as well as on tests of generic quality of life (Short Form-36 (SF-36)), mood (Beck Depression Inventory, Hospital Anxiety and Depression Rating Scale), and pain (McGill Pain Questionnaire, Headache Impact Test, Pain Behaviour Checklist). Results The CH-QoL total score was significantly reduced after compared to before VTA-DBS. Changes in the CH-QoL total score correlated significantly and negatively with changes in HAL, the SF-36, and positively and significantly with depression and the evaluative domain on the McGill Pain Questionnaire. Conclusions Our findings demonstrate that changes after VTA-DBS in CH-QoL total scores are associated with the reduction of frequency, duration, and severity of headache attacks after surgery. Moreover, post VTA-DBS improvement in CH-QoL scores is associated with an amelioration in quality of life assessed with generic measures, a reduction of depressive symptoms, and evaluative pain experience after VTA-DBS. These results support the sensitivity to change of the CH-QoL and further demonstrate the validity and applicability of CH-QoL as a disease specific measure of quality of life for CH.
topic Cluster headache
Trigeminal autonomic cephalalgias
Quality of life scale
Deep brain stimulation
url https://doi.org/10.1186/s10194-021-01251-5
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spelling doaj-ba02e61135e84323a0f8eaed841589532021-06-13T11:25:51ZengBMCThe Journal of Headache and Pain1129-23691129-23772021-06-012211810.1186/s10194-021-01251-5The sensitivity to change of the cluster headache quality of life scale assessed before and after deep brain stimulation of the ventral tegmental areaDavide Cappon0Agata Ryterska1Harith Akram2Susie Lagrata3Sanjay Cheema4Jonathan Hyam5Ludvic Zrinzo6Manjit Matharu7Marjan Jahanshahi8Unit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, University College London (UCL) Institute of Neurology, National Hospital for Neurology and NeurosurgeryUnit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, University College London (UCL) Institute of Neurology, National Hospital for Neurology and NeurosurgeryUnit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, University College London (UCL) Institute of Neurology, National Hospital for Neurology and NeurosurgeryHeadache and Facial Pain Group, UCL Queen Square Institute of Neurology, The National Hospital for Neurology and NeurosurgeryDepartment of Psychology, Queen Mary University of LondonUnit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, University College London (UCL) Institute of Neurology, National Hospital for Neurology and NeurosurgeryUnit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, University College London (UCL) Institute of Neurology, National Hospital for Neurology and NeurosurgeryDepartment of Psychology, Queen Mary University of LondonUnit of Functional Neurosurgery, Department of Clinical and Movement Neurosciences, University College London (UCL) Institute of Neurology, National Hospital for Neurology and NeurosurgeryAbstract Background Cluster headache (CH) is a trigeminal autonomic cephalalgia (TAC) characterized by a highly disabling headache that negatively impacts quality of life and causes limitations in daily functioning as well as social functioning and family life. Since specific measures to assess the quality of life (QoL) in TACs are lacking, we recently developed and validated the cluster headache quality of life scale (CH-QoL). The sensitivity of CH-QoL to change after a medical intervention has not been evaluated yet. Methods This study aimed to test the sensitivity to change of the CH-QoL in CH. Specifically we aimed to (i) assess the sensitivity of CH-QoL to change before and following deep brain stimulation of the ventral tegmental area (VTA-DBS), (ii) evaluate the relationship of changes on CH-QoL with changes in other generic measures of quality of life, as well as indices of mood and pain. Ten consecutive CH patients completed the CH-QoL and underwent neuropsychological assessment before and after VTA-DBS. The patients were evaluated on headache frequency, severity, and load (HAL) as well as on tests of generic quality of life (Short Form-36 (SF-36)), mood (Beck Depression Inventory, Hospital Anxiety and Depression Rating Scale), and pain (McGill Pain Questionnaire, Headache Impact Test, Pain Behaviour Checklist). Results The CH-QoL total score was significantly reduced after compared to before VTA-DBS. Changes in the CH-QoL total score correlated significantly and negatively with changes in HAL, the SF-36, and positively and significantly with depression and the evaluative domain on the McGill Pain Questionnaire. Conclusions Our findings demonstrate that changes after VTA-DBS in CH-QoL total scores are associated with the reduction of frequency, duration, and severity of headache attacks after surgery. Moreover, post VTA-DBS improvement in CH-QoL scores is associated with an amelioration in quality of life assessed with generic measures, a reduction of depressive symptoms, and evaluative pain experience after VTA-DBS. These results support the sensitivity to change of the CH-QoL and further demonstrate the validity and applicability of CH-QoL as a disease specific measure of quality of life for CH.https://doi.org/10.1186/s10194-021-01251-5Cluster headacheTrigeminal autonomic cephalalgiasQuality of life scaleDeep brain stimulation