Revisiting antithrombotic therapeutics; sculptin, a novel specific, competitive, reversible, scissile and tight binding inhibitor of thrombin
Abstract Thrombin is a multifunctional enzyme with a key role in the coagulation cascade. Its functional modulation can culminate into normal blood coagulation or thrombosis. Thus, the identification of novel potent inhibitors of thrombin are of immense importance. Sculptin is the first specific thr...
Main Authors: | Asif Iqbal, Mauricio Barbugiani Goldfeder, Rafael Marques-Porto, Huma Asif, Jean Gabriel de Souza, Fernanda Faria, Ana Marisa Chudzinski-Tavassi |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-05-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-017-01486-w |
Similar Items
-
Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells
by: Mariana Costa Braga Schmidt, et al.
Published: (2020-01-01) -
An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII.
by: Behnaz Pezeshkpoor, et al.
Published: (2017-01-01) -
Caracterização funcional da proteína Cwc24p de Saccharomyces cerevisiae
by: Mauricio Barbugiani Goldfeder
Published: (2008) -
Caracterização funcional da proteína Cwc24p de Saccharomyces cerevisiae
by: Goldfeder, Mauricio Barbugiani
Published: (2008) -
Antithrombotic effect of Lonomia obliqua caterpillar bristle extract on experimental venous thrombosis
by: B.C. Prezoto, et al.
Published: (2002-06-01)