Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes

More than 100 risk loci for schizophrenia have been identified by genome-wide association studies. Here, the authors apply an integrative genomic approach to prioritize risk genes and validate GLT8D1 and CSNK2B as candidate causal genes by in vitro studies in neural stem cells.

Bibliographic Details
Main Authors:	Cui-Ping Yang, Xiaoyan Li, Yong Wu, Qiushuo Shen, Yong Zeng, Qiuxia Xiong, Mengping Wei, Chunhui Chen, Jiewei Liu, Yongxia Huo, Kaiqin Li, Gui Xue, Yong-Gang Yao, Chen Zhang, Ming Li, Yongbin Chen, Xiong-Jian Luo
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03247-3

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spelling	doaj-ba12e6b9e8a940f9954895f9f71b14082021-05-11T10:08:52ZengNature Publishing GroupNature Communications2041-17232018-02-019111610.1038/s41467-018-03247-3Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genesCui-Ping Yang0Xiaoyan Li1Yong Wu2Qiushuo Shen3Yong Zeng4Qiuxia Xiong5Mengping Wei6Chunhui Chen7Jiewei Liu8Yongxia Huo9Kaiqin Li10Gui Xue11Yong-Gang Yao12Chen Zhang13Ming Li14Yongbin Chen15Xiong-Jian Luo16Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical CollegeDepartment of Psychiatry, The First Affiliated Hospital of Kunming Medical CollegeState Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences, Peking UniversityState Key Laboratory of Cognitive Neuroscience and Learning, and IDG/McGovern Institute for Brain Research, Beijing Normal UniversityKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Cognitive Neuroscience and Learning, and IDG/McGovern Institute for Brain Research, Beijing Normal UniversityKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Membrane Biology, PKU-IDG/McGovern Institute for Brain Research, School of Life Sciences, Peking UniversityKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesKey Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of SciencesMore than 100 risk loci for schizophrenia have been identified by genome-wide association studies. Here, the authors apply an integrative genomic approach to prioritize risk genes and validate GLT8D1 and CSNK2B as candidate causal genes by in vitro studies in neural stem cells.https://doi.org/10.1038/s41467-018-03247-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Cui-Ping Yang Xiaoyan Li Yong Wu Qiushuo Shen Yong Zeng Qiuxia Xiong Mengping Wei Chunhui Chen Jiewei Liu Yongxia Huo Kaiqin Li Gui Xue Yong-Gang Yao Chen Zhang Ming Li Yongbin Chen Xiong-Jian Luo
spellingShingle	Cui-Ping Yang Xiaoyan Li Yong Wu Qiushuo Shen Yong Zeng Qiuxia Xiong Mengping Wei Chunhui Chen Jiewei Liu Yongxia Huo Kaiqin Li Gui Xue Yong-Gang Yao Chen Zhang Ming Li Yongbin Chen Xiong-Jian Luo Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes Nature Communications
author_facet	Cui-Ping Yang Xiaoyan Li Yong Wu Qiushuo Shen Yong Zeng Qiuxia Xiong Mengping Wei Chunhui Chen Jiewei Liu Yongxia Huo Kaiqin Li Gui Xue Yong-Gang Yao Chen Zhang Ming Li Yongbin Chen Xiong-Jian Luo
author_sort	Cui-Ping Yang
title	Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
title_short	Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
title_full	Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
title_fullStr	Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
title_full_unstemmed	Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes
title_sort	comprehensive integrative analyses identify glt8d1 and csnk2b as schizophrenia risk genes
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-02-01
description	More than 100 risk loci for schizophrenia have been identified by genome-wide association studies. Here, the authors apply an integrative genomic approach to prioritize risk genes and validate GLT8D1 and CSNK2B as candidate causal genes by in vitro studies in neural stem cells.
url	https://doi.org/10.1038/s41467-018-03247-3
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Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes

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