Interleukin-35 on B cell and T cell induction and regulation

• Main Authors: Ai Huang, Lin Cheng, Miao He, Jun Nie, Jianjun Wang, Ke Jiang
• Format: Article
• Language: English
• Published: BMC 2017-08-01
• Series: Journal of Inflammation
• Subjects: Interleukin −35; B cells; T cells
• Online Access: http://link.springer.com/article/10.1186/s12950-017-0164-5
• ISSN: 1476-9255

Abstract Interleukin (IL)-35 is a relatively newly discovered member of IL-12 cytokine family that is unique in that it is a dimer formed by two subunits. The review documents the structure, secretion and signal transduction of IL-35, the regulation effect of IL-35 on B cells and T cells as well as the adoptive transfer of IL-35+ regulatory B cells (Breg), therapeutic prospects of recombinant IL-35 (rIL-35) and IL-35 regulation role in various diseases. B-cell regulation expands the regulatory range of IL-35 and alters the view that IL-10 is the chief immune mechanism for Breg cells which secrete IL-35. IL-35 induces Breg cells, which then can induce Treg cells. IL-35 also plays an immunomodulatory role in the human body.