Generation of NERCe003-A-3, a p53 compound heterozygous mutation human embryonic stem cell line, by CRISPR/Cas9 editing

Generation of NERCe003-A-3, a p53 compound heterozygous mutation human embryonic stem cell line, by CRISPR/Cas9 editing

p53 is a tumor suppressor gene involved mainly in the regulation of the G1/S cell cycle phase, DNA repair, and senescence. Although p53 is frequently altered in human cancer, the consequences of its depletion in human embryonic stem cells (hESCs) are unknown. We generated NERCe003-A-3, a p53 knockou...

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Bibliographic Details
Main Authors: Yingkang Li, Chuan Huang, Lagabaiyila Zha, Mingyue Kong, Qiaohui Yang, Yinghong Zhu, Yingying Peng, Qi Ouyang, Guangxiu Lu, Ge Lin, Di Zhou
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506118303064

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