Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone.

Critical role of activating transcription factor 4 in the anabolic actions of parathyroid hormone in bone.

Parathyroid hormone (PTH) is a potent anabolic agent for the treatment of osteoporosis. However, its mechanism of action in osteoblast and bone is not well understood. In this study, we show that the anabolic actions of PTH in bone are severely impaired in both growing and adult ovariectomized mice...

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Main Authors: Shibing Yu, Renny T Franceschi, Min Luo, Jie Fan, Di Jiang, Huiling Cao, Tae-Geon Kwon, Yumei Lai, Jian Zhang, Kenneth Patrene, Kurt Hankenson, G David Roodman, Guozhi Xiao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2762317?pdf=render

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