Possible mechanisms of lack of dentin bridge formation in response to calcium hydroxide in primary teeth

Introduction: The usage of Calcium hydroxide (CaOH2) has wide applications due to the property of osteo-inductive, protective, and antibacterial actions. However, it is not used in primary teeth, as it fails to form reparative dentin and the exact mechanism has not been explained. The hypothesis: Th...

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Main Authors: G R Ravi, R V Subramanyam
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Dental Hypotheses
Subjects:
Online Access:http://www.dentalhypotheses.com/article.asp?issn=2155-8213;year=2015;volume=6;issue=1;spage=6;epage=9;aulast=Ravi
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spelling doaj-ba2f68b7c1654a17841145529a8539a42020-11-25T00:21:28ZengWolters Kluwer Medknow PublicationsDental Hypotheses2155-82132015-01-01616910.4103/2155-8213.150863Possible mechanisms of lack of dentin bridge formation in response to calcium hydroxide in primary teethG R RaviR V SubramanyamIntroduction: The usage of Calcium hydroxide (CaOH2) has wide applications due to the property of osteo-inductive, protective, and antibacterial actions. However, it is not used in primary teeth, as it fails to form reparative dentin and the exact mechanism has not been explained. The hypothesis: The authors propose an explanation that lack of dentin bridge formation in response to (CaOH2) in primary teeth could be multifactorial: inability of the deciduous stem cells to generate complete dentin-pulp-like tissue; the absence of calcium-magnesium-dependent adenosine triphosphatase (Ca-Mg ATPase) in the odontoblasts; the pre-existing predilection of deciduous dentine pulp to form odontoclasts; the solubility of (CaOH2). Evaluation of the hypothesis: The hypothesis discusses the innate traits of the deciduous stem cells that lack the ability to form the dentin bridge, the absence of Ca-Mg ATPase enzyme and increased solubility of (CaOH2) together fail to stimulate the odontoblasts. Alternatively, pre-existing progenitor cells with proclivity to change into odontoclasts may cause internal resorption and hamper formation of reparative dentin.http://www.dentalhypotheses.com/article.asp?issn=2155-8213;year=2015;volume=6;issue=1;spage=6;epage=9;aulast=RaviCalcium hydroxideCa-Mg ATPasedentin bridgedeciduous teethprimary teethtooth resorption
collection DOAJ
language English
format Article
sources DOAJ
author G R Ravi
R V Subramanyam
spellingShingle G R Ravi
R V Subramanyam
Possible mechanisms of lack of dentin bridge formation in response to calcium hydroxide in primary teeth
Dental Hypotheses
Calcium hydroxide
Ca-Mg ATPase
dentin bridge
deciduous teeth
primary teeth
tooth resorption
author_facet G R Ravi
R V Subramanyam
author_sort G R Ravi
title Possible mechanisms of lack of dentin bridge formation in response to calcium hydroxide in primary teeth
title_short Possible mechanisms of lack of dentin bridge formation in response to calcium hydroxide in primary teeth
title_full Possible mechanisms of lack of dentin bridge formation in response to calcium hydroxide in primary teeth
title_fullStr Possible mechanisms of lack of dentin bridge formation in response to calcium hydroxide in primary teeth
title_full_unstemmed Possible mechanisms of lack of dentin bridge formation in response to calcium hydroxide in primary teeth
title_sort possible mechanisms of lack of dentin bridge formation in response to calcium hydroxide in primary teeth
publisher Wolters Kluwer Medknow Publications
series Dental Hypotheses
issn 2155-8213
publishDate 2015-01-01
description Introduction: The usage of Calcium hydroxide (CaOH2) has wide applications due to the property of osteo-inductive, protective, and antibacterial actions. However, it is not used in primary teeth, as it fails to form reparative dentin and the exact mechanism has not been explained. The hypothesis: The authors propose an explanation that lack of dentin bridge formation in response to (CaOH2) in primary teeth could be multifactorial: inability of the deciduous stem cells to generate complete dentin-pulp-like tissue; the absence of calcium-magnesium-dependent adenosine triphosphatase (Ca-Mg ATPase) in the odontoblasts; the pre-existing predilection of deciduous dentine pulp to form odontoclasts; the solubility of (CaOH2). Evaluation of the hypothesis: The hypothesis discusses the innate traits of the deciduous stem cells that lack the ability to form the dentin bridge, the absence of Ca-Mg ATPase enzyme and increased solubility of (CaOH2) together fail to stimulate the odontoblasts. Alternatively, pre-existing progenitor cells with proclivity to change into odontoclasts may cause internal resorption and hamper formation of reparative dentin.
topic Calcium hydroxide
Ca-Mg ATPase
dentin bridge
deciduous teeth
primary teeth
tooth resorption
url http://www.dentalhypotheses.com/article.asp?issn=2155-8213;year=2015;volume=6;issue=1;spage=6;epage=9;aulast=Ravi
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