Recent advances in deep brain stimulation in psychiatric disorders [version 1; referees: 2 approved]
Deep brain stimulation (DBS) has been offered to patients suffering of severe and resistant neuropsychiatric disorders like Obsessive Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (TS) and Major Depression (MDD). Modulation of several targets within the cortico-striato-thalamo-cortical c...
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doaj-ba3cc0ad7173436f9772cde4b62745e02020-11-25T03:48:15ZengF1000 Research LtdF1000Research2046-14022018-06-01710.12688/f1000research.14187.115432Recent advances in deep brain stimulation in psychiatric disorders [version 1; referees: 2 approved]Anne-Hélène Clair0William Haynes1Luc Mallet2Sorbonne University, UPMC Paris 06 University, INSERM, CNRS, Institut du Cerveau et de la Moelle épinière, Paris, FranceSorbonne University, UPMC Paris 06 University, INSERM, CNRS, Institut du Cerveau et de la Moelle épinière, Paris, FranceSorbonne University, UPMC Paris 06 University, INSERM, CNRS, Institut du Cerveau et de la Moelle épinière, Paris, FranceDeep brain stimulation (DBS) has been offered to patients suffering of severe and resistant neuropsychiatric disorders like Obsessive Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (TS) and Major Depression (MDD). Modulation of several targets within the cortico-striato-thalamo-cortical circuits can lead to a decrease of symptom severity in those patients. This review focuses on the recent clinical outcomes in DBS in psychiatric disorders. Studies on OCD and TS are now focusing on the long-term effects of DBS, with encouraging results regarding not only the decrease of symptoms, but also quality of life. They also highlighted efficient adjuvant techniques, like cognitive and behavioural therapy and support programs, to enhance an often-partial response to DBS. The application of DBS for MDD is more recent and, despite encouraging initial open-label studies, two large randomised studies have failed to demonstrate an efficacy of DBS in MDD according to evidence-based medicine criteria. Last years, DBS was also tested in other resistant psychiatric disorders, as anorexia nervosa and addiction, with encouraging preliminary results. However, today, no target – whatever the disease – can meet the criteria for clinical efficacy as recently defined by an international committee for neurosurgery for psychiatric disorders. Consequently, DBS in psychiatric disorders still needs to proceed within the frame of clinical trials.https://f1000research.com/articles/7-699/v1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anne-Hélène Clair William Haynes Luc Mallet |
spellingShingle |
Anne-Hélène Clair William Haynes Luc Mallet Recent advances in deep brain stimulation in psychiatric disorders [version 1; referees: 2 approved] F1000Research |
author_facet |
Anne-Hélène Clair William Haynes Luc Mallet |
author_sort |
Anne-Hélène Clair |
title |
Recent advances in deep brain stimulation in psychiatric disorders [version 1; referees: 2 approved] |
title_short |
Recent advances in deep brain stimulation in psychiatric disorders [version 1; referees: 2 approved] |
title_full |
Recent advances in deep brain stimulation in psychiatric disorders [version 1; referees: 2 approved] |
title_fullStr |
Recent advances in deep brain stimulation in psychiatric disorders [version 1; referees: 2 approved] |
title_full_unstemmed |
Recent advances in deep brain stimulation in psychiatric disorders [version 1; referees: 2 approved] |
title_sort |
recent advances in deep brain stimulation in psychiatric disorders [version 1; referees: 2 approved] |
publisher |
F1000 Research Ltd |
series |
F1000Research |
issn |
2046-1402 |
publishDate |
2018-06-01 |
description |
Deep brain stimulation (DBS) has been offered to patients suffering of severe and resistant neuropsychiatric disorders like Obsessive Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (TS) and Major Depression (MDD). Modulation of several targets within the cortico-striato-thalamo-cortical circuits can lead to a decrease of symptom severity in those patients. This review focuses on the recent clinical outcomes in DBS in psychiatric disorders. Studies on OCD and TS are now focusing on the long-term effects of DBS, with encouraging results regarding not only the decrease of symptoms, but also quality of life. They also highlighted efficient adjuvant techniques, like cognitive and behavioural therapy and support programs, to enhance an often-partial response to DBS. The application of DBS for MDD is more recent and, despite encouraging initial open-label studies, two large randomised studies have failed to demonstrate an efficacy of DBS in MDD according to evidence-based medicine criteria. Last years, DBS was also tested in other resistant psychiatric disorders, as anorexia nervosa and addiction, with encouraging preliminary results. However, today, no target – whatever the disease – can meet the criteria for clinical efficacy as recently defined by an international committee for neurosurgery for psychiatric disorders. Consequently, DBS in psychiatric disorders still needs to proceed within the frame of clinical trials. |
url |
https://f1000research.com/articles/7-699/v1 |
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