Mechanisms of microRNA-mediated gene regulation in unicellular model alga Chlamydomonas reinhardtii
Abstract MicroRNAs are a class of endogenous non-coding RNAs that play a vital role in post-transcriptional gene regulation in eukaryotic cells. In plants and animals, miRNAs are implicated in diverse roles ranging from immunity against viral infections, developmental pathways, molecular pathology o...
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doaj-ba575cb72ce54c0abe1127a35cbecd2c2020-11-25T00:25:02ZengBMCBiotechnology for Biofuels1754-68342018-09-0111111210.1186/s13068-018-1249-yMechanisms of microRNA-mediated gene regulation in unicellular model alga Chlamydomonas reinhardtiiSulin Lou0Ting Sun1Hui Li2Zhangli Hu3Guangdong Key Laboratory of Plant Epigenetics, Guangdong Engineering Research Center for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen UniversityGuangdong Key Laboratory of Plant Epigenetics, Guangdong Engineering Research Center for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen UniversityGuangdong Key Laboratory of Plant Epigenetics, Guangdong Engineering Research Center for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen UniversityGuangdong Key Laboratory of Plant Epigenetics, Guangdong Engineering Research Center for Marine Algal Biotechnology, Longhua Innovation Institute for Biotechnology, College of Life Sciences and Oceanography, Shenzhen UniversityAbstract MicroRNAs are a class of endogenous non-coding RNAs that play a vital role in post-transcriptional gene regulation in eukaryotic cells. In plants and animals, miRNAs are implicated in diverse roles ranging from immunity against viral infections, developmental pathways, molecular pathology of cancer and regulation of protein expression. However, the role of miRNAs in the unicellular model green alga Chlamydomonas reinhardtii remains unclear. The mode of action of miRNA-induced gene silencing in C. reinhardtii is very similar to that of higher eukaryotes, in terms of the activation of the RNA-induced silencing complex and mRNA targeting. Certain studies indicate that destabilization of mRNAs and mRNA turnover could be the major possible functions of miRNAs in eukaryotic algae. Here, we summarize recent findings that have advanced our understanding of miRNA regulatory mechanisms in C. reinhardtii.http://link.springer.com/article/10.1186/s13068-018-1249-ymiRNABiogenesisMode of actionRegulatory mechanismsUnicellularMicroalgae |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sulin Lou Ting Sun Hui Li Zhangli Hu |
spellingShingle |
Sulin Lou Ting Sun Hui Li Zhangli Hu Mechanisms of microRNA-mediated gene regulation in unicellular model alga Chlamydomonas reinhardtii Biotechnology for Biofuels miRNA Biogenesis Mode of action Regulatory mechanisms Unicellular Microalgae |
author_facet |
Sulin Lou Ting Sun Hui Li Zhangli Hu |
author_sort |
Sulin Lou |
title |
Mechanisms of microRNA-mediated gene regulation in unicellular model alga Chlamydomonas reinhardtii |
title_short |
Mechanisms of microRNA-mediated gene regulation in unicellular model alga Chlamydomonas reinhardtii |
title_full |
Mechanisms of microRNA-mediated gene regulation in unicellular model alga Chlamydomonas reinhardtii |
title_fullStr |
Mechanisms of microRNA-mediated gene regulation in unicellular model alga Chlamydomonas reinhardtii |
title_full_unstemmed |
Mechanisms of microRNA-mediated gene regulation in unicellular model alga Chlamydomonas reinhardtii |
title_sort |
mechanisms of microrna-mediated gene regulation in unicellular model alga chlamydomonas reinhardtii |
publisher |
BMC |
series |
Biotechnology for Biofuels |
issn |
1754-6834 |
publishDate |
2018-09-01 |
description |
Abstract MicroRNAs are a class of endogenous non-coding RNAs that play a vital role in post-transcriptional gene regulation in eukaryotic cells. In plants and animals, miRNAs are implicated in diverse roles ranging from immunity against viral infections, developmental pathways, molecular pathology of cancer and regulation of protein expression. However, the role of miRNAs in the unicellular model green alga Chlamydomonas reinhardtii remains unclear. The mode of action of miRNA-induced gene silencing in C. reinhardtii is very similar to that of higher eukaryotes, in terms of the activation of the RNA-induced silencing complex and mRNA targeting. Certain studies indicate that destabilization of mRNAs and mRNA turnover could be the major possible functions of miRNAs in eukaryotic algae. Here, we summarize recent findings that have advanced our understanding of miRNA regulatory mechanisms in C. reinhardtii. |
topic |
miRNA Biogenesis Mode of action Regulatory mechanisms Unicellular Microalgae |
url |
http://link.springer.com/article/10.1186/s13068-018-1249-y |
work_keys_str_mv |
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1725350231878402048 |