Existence of molten globule state in homocysteine-induced protein covalent modifications.
Homocysteine thiolactone is a toxic metabolite produced from homocysteine by amino-acyl t-RNA synthetase in error editing reaction. The basic cause of toxicity of homocysteine thiolactone is believed to be due to the adduct formation with lysine residues (known as protein N-homocysteinylation) leadi...
Main Authors: | Tarun Kumar, Gurumayum Suraj Sharma, Laishram Rajendrakumar Singh |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4236184?pdf=render |
Similar Items
-
Functional inhibition of redox regulated heme proteins: A novel mechanism towards oxidative stress induced by homocysteine
by: Gurumayum Suraj Sharma, et al.
Published: (2021-10-01) -
N-homocysteinylation induces different structural and functional consequences on acidic and basic proteins.
by: Gurumayum Suraj Sharma, et al.
Published: (2014-01-01) -
Disturbed homocysteine metabolism is associated with cancer
by: Tauheed Hasan, et al.
Published: (2019-02-01) -
The Molten Globule, and Two-State vs. Non-Two-State Folding of Globular Proteins
by: Kunihiro Kuwajima
Published: (2020-03-01) -
Structural characteristic of the initial unfolded state on refolding determines catalytic efficiency of the folded protein in presence of osmolytes.
by: Marina Warepam, et al.
Published: (2014-01-01)