TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation

TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation

Osteoimmunology peeks into the interaction of bone and the immune system, which has largely proved to be a multiplex reaction. Osteocytes have been shown to regulate bone resorption through the expression of RANKL in physiologic and pathologic conditions. TNF-α, a product of the immune system, is an...

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Bibliographic Details
Main Authors: Aseel Marahleh, Hideki Kitaura, Fumitoshi Ohori, Akiko Kishikawa, Saika Ogawa, Wei-Ren Shen, Jiawei Qi, Takahiro Noguchi, Yasuhiko Nara, Itaru Mizoguchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
osteocyte
TNF-α
RANKL
osteoimmunology
osteoclastogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02925/full

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