TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation
Osteoimmunology peeks into the interaction of bone and the immune system, which has largely proved to be a multiplex reaction. Osteocytes have been shown to regulate bone resorption through the expression of RANKL in physiologic and pathologic conditions. TNF-α, a product of the immune system, is an...
Main Authors: | Aseel Marahleh, Hideki Kitaura, Fumitoshi Ohori, Akiko Kishikawa, Saika Ogawa, Wei-Ren Shen, Jiawei Qi, Takahiro Noguchi, Yasuhiko Nara, Itaru Mizoguchi |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-12-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02925/full |
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