Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network
Hypoxia-inducible factor-1 (HIF-1)–induced angiogenesis has been involved in numerous pathological conditions, and it may be harmful or beneficial depending on the types of diseases. Exploration on angiogenesis has sparked hopes in providing novel therapeutic approaches on multiple diseases with hig...
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doaj-ba65e62fc9d54e759ee0a645308d13082020-11-24T23:52:57ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-06-011010.3389/fphar.2019.00696442096Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 NetworkMing Hong0Honglian Shi1Ning Wang2Hor-Yue Tan3Qi Wang4Yibin Feng5Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Pharmacology and Toxicology, University of Kansas, Lawrence, KS, United StatesSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong KongSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong KongInstitute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, ChinaSchool of Chinese Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong KongHypoxia-inducible factor-1 (HIF-1)–induced angiogenesis has been involved in numerous pathological conditions, and it may be harmful or beneficial depending on the types of diseases. Exploration on angiogenesis has sparked hopes in providing novel therapeutic approaches on multiple diseases with high mortality rates, such as cancer and ischemic stroke. The HIF-1 pathway is considered to be a major regulator of angiogenesis. HIF-1 seems to be involved in the vascular formation process by synergistic correlations with other proangiogenic factors in cancer and cerebrovascular disease. The regulation of HIF-1–dependent angiogenesis is related to the modulation of HIF-1 bioactivity by regulating HIF-1α transcription or protein translation, HIF-1α DNA binding, HIF-1α and HIF-1α dimerization, and HIF-1 degradation. Traditional Chinese herbal medicines have a long history of clinical use in both cancer and stroke treatments in Asia. Growing evidence has demonstrated potential proangiogenic benefits of Chinese herbal medicines in ischemic stroke, whereas tumor angiogenesis could be inhibited by the active components in Chinese herbal medicines. The objective of this review is to provide comprehensive insight on the effects of Chinese herbal medicines on angiogenesis by regulating HIF-1 pathways in both cancer and ischemic stroke.https://www.frontiersin.org/article/10.3389/fphar.2019.00696/fullangiogenesisherbal medicinehypoxia-inducible factor-1cancerischemic stroke |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ming Hong Honglian Shi Ning Wang Hor-Yue Tan Qi Wang Yibin Feng |
spellingShingle |
Ming Hong Honglian Shi Ning Wang Hor-Yue Tan Qi Wang Yibin Feng Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network Frontiers in Pharmacology angiogenesis herbal medicine hypoxia-inducible factor-1 cancer ischemic stroke |
author_facet |
Ming Hong Honglian Shi Ning Wang Hor-Yue Tan Qi Wang Yibin Feng |
author_sort |
Ming Hong |
title |
Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network |
title_short |
Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network |
title_full |
Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network |
title_fullStr |
Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network |
title_full_unstemmed |
Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network |
title_sort |
dual effects of chinese herbal medicines on angiogenesis in cancer and ischemic stroke treatments: role of hif-1 network |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2019-06-01 |
description |
Hypoxia-inducible factor-1 (HIF-1)–induced angiogenesis has been involved in numerous pathological conditions, and it may be harmful or beneficial depending on the types of diseases. Exploration on angiogenesis has sparked hopes in providing novel therapeutic approaches on multiple diseases with high mortality rates, such as cancer and ischemic stroke. The HIF-1 pathway is considered to be a major regulator of angiogenesis. HIF-1 seems to be involved in the vascular formation process by synergistic correlations with other proangiogenic factors in cancer and cerebrovascular disease. The regulation of HIF-1–dependent angiogenesis is related to the modulation of HIF-1 bioactivity by regulating HIF-1α transcription or protein translation, HIF-1α DNA binding, HIF-1α and HIF-1α dimerization, and HIF-1 degradation. Traditional Chinese herbal medicines have a long history of clinical use in both cancer and stroke treatments in Asia. Growing evidence has demonstrated potential proangiogenic benefits of Chinese herbal medicines in ischemic stroke, whereas tumor angiogenesis could be inhibited by the active components in Chinese herbal medicines. The objective of this review is to provide comprehensive insight on the effects of Chinese herbal medicines on angiogenesis by regulating HIF-1 pathways in both cancer and ischemic stroke. |
topic |
angiogenesis herbal medicine hypoxia-inducible factor-1 cancer ischemic stroke |
url |
https://www.frontiersin.org/article/10.3389/fphar.2019.00696/full |
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