Review on Different Action Mechanisms of PDGF-BB on Glomerular Mesangial Cell Proliferation

• Main Authors: CHEN Sha-sha, REN Xian-zhi
• Format: Article
• Language: English
• Published: Third Party Medicine International Publishing Group Co. Limited 2014-09-01
• Series: Journal of International Translational Medicine
• Subjects: Platelet-derived growth factor (PDGF) -BB; Mesangial cell; Proliferation; Mechanism
• Online Access: http://www.jitm.hk/EN/10.11910/2227-6394.2014.02.03.15

Platelet-derived growth factor BB (PDGF-BB) and PDGF receptor-β (PDGFR) play critical roles in proliferation and envolving into MsPGN of mesangial cells in embryonic development. The mechanisms can be demonstrated mainly from several aspects such as promoting the proliferation of glomerular mesangial cells (GMC), stimulating the GMC expression of extracellular matrix components and synergism with other growth factors like transform growth factor-β (TGF-β) and so on. As in the pathological development of mesangial proliferative lesions, GMCs is not only the victim of kidney damage but also the direct participants. GMCs can secrete excessive PDGF - BB and other growth factors which could react to GMCs, leading to malignant progress of kidney damage. Therefore, inhibiting GMCs over expression of PDGF-BB and blocking the effect of PDGF-BB on promoting proliferation and ECM accumulation is undoubtedly an effective way to delay kidney damage.