Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus

Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus

Toxic epidermal necrolysis (TEN) has been long believed to be the most severe manifestation of drug allergy. However, cutaneous changes as TEN in systemic lupus erythematosus (SLE) were first described in the late 1970s. As of now, the English-language literature published reports of 30 cases of suc...

Full description

Bibliographic Details
Main Authors: L. D. Vorobyeva, E. A. Aseeva, S. K. Solovyev, T. A. Belousova, N. E. Lopatina, E. G. Sazhina, G. V. Serikova
Format: Article
Language:Russian
Published: IMA-PRESS LLC 2019-01-01
Series:Научно-практическая ревматология
Subjects:
toxic epidermal necrolysis
systemic lupus erythematosus
clinical case
intravenous immunoglobulin
rituximab
Online Access:https://rsp.mediar-press.net/rsp/article/view/2658
Description
Summary:Toxic epidermal necrolysis (TEN) has been long believed to be the most severe manifestation of drug allergy. However, cutaneous changes as TEN in systemic lupus erythematosus (SLE) were first described in the late 1970s. As of now, the English-language literature published reports of 30 cases of such lesions in SLE. This paper describes a clinical case of TEN as a direct manifestation of SLE; the positive experience has been first depicted in using not only intravenous immunoglobulin, but also rituximab with a good therapeutic effect in Russian clinical practice.
ISSN:1995-4484
1995-4492

Similar Items