Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus

Toxic epidermal necrolysis (TEN) has been long believed to be the most severe manifestation of drug allergy. However, cutaneous changes as TEN in systemic lupus erythematosus (SLE) were first described in the late 1970s. As of now, the English-language literature published reports of 30 cases of suc...

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Main Authors:	L. D. Vorobyeva, E. A. Aseeva, S. K. Solovyev, T. A. Belousova, N. E. Lopatina, E. G. Sazhina, G. V. Serikova
Format:	Article
Language:	Russian
Published:	IMA-PRESS LLC 2019-01-01
Series:	Научно-практическая ревматология
Subjects:	toxic epidermal necrolysis systemic lupus erythematosus clinical case intravenous immunoglobulin rituximab
Online Access:	https://rsp.mediar-press.net/rsp/article/view/2658

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spelling	doaj-ba68717e2b1b4d9cbcb082f6995784102021-08-02T09:05:52ZrusIMA-PRESS LLCНаучно-практическая ревматология1995-44841995-44922019-01-0156678579010.14412/1995-4484-2018-785-7902437Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosusL. D. Vorobyeva0E. A. Aseeva1S. K. Solovyev2T. A. Belousova3N. E. Lopatina4E. G. Sazhina5G. V. Serikova6V.A. Nasonova Research Institute of Rheumatology.V.A. Nasonova Research Institute of Rheumatology.V.A. Nasonova Research Institute of Rheumatology.Department of Skin and Venereal Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia.V.A. Nasonova Research Institute of Rheumatology.V.A. Nasonova Research Institute of Rheumatology.V.A. Nasonova Research Institute of Rheumatology.Toxic epidermal necrolysis (TEN) has been long believed to be the most severe manifestation of drug allergy. However, cutaneous changes as TEN in systemic lupus erythematosus (SLE) were first described in the late 1970s. As of now, the English-language literature published reports of 30 cases of such lesions in SLE. This paper describes a clinical case of TEN as a direct manifestation of SLE; the positive experience has been first depicted in using not only intravenous immunoglobulin, but also rituximab with a good therapeutic effect in Russian clinical practice.https://rsp.mediar-press.net/rsp/article/view/2658toxic epidermal necrolysissystemic lupus erythematosusclinical caseintravenous immunoglobulinrituximab
collection	DOAJ
language	Russian
format	Article
sources	DOAJ
author	L. D. Vorobyeva E. A. Aseeva S. K. Solovyev T. A. Belousova N. E. Lopatina E. G. Sazhina G. V. Serikova
spellingShingle	L. D. Vorobyeva E. A. Aseeva S. K. Solovyev T. A. Belousova N. E. Lopatina E. G. Sazhina G. V. Serikova Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus Научно-практическая ревматология toxic epidermal necrolysis systemic lupus erythematosus clinical case intravenous immunoglobulin rituximab
author_facet	L. D. Vorobyeva E. A. Aseeva S. K. Solovyev T. A. Belousova N. E. Lopatina E. G. Sazhina G. V. Serikova
author_sort	L. D. Vorobyeva
title	Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus
title_short	Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus
title_full	Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus
title_fullStr	Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus
title_full_unstemmed	Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus
title_sort	toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus
publisher	IMA-PRESS LLC
series	Научно-практическая ревматология
issn	1995-4484 1995-4492
publishDate	2019-01-01
description	Toxic epidermal necrolysis (TEN) has been long believed to be the most severe manifestation of drug allergy. However, cutaneous changes as TEN in systemic lupus erythematosus (SLE) were first described in the late 1970s. As of now, the English-language literature published reports of 30 cases of such lesions in SLE. This paper describes a clinical case of TEN as a direct manifestation of SLE; the positive experience has been first depicted in using not only intravenous immunoglobulin, but also rituximab with a good therapeutic effect in Russian clinical practice.
topic	toxic epidermal necrolysis systemic lupus erythematosus clinical case intravenous immunoglobulin rituximab
url	https://rsp.mediar-press.net/rsp/article/view/2658
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Toxic epidermal necrolysis as a variant of severe skin lesions in systemic lupus erythematosus

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