Impact of Glycosylation on Effector Functions of Therapeutic IgG
Human IgG has only one conserved glycosylation site located in the Cγ2 domain of the Fc region that accounts for the presence of two sugar moieties per IgG. These IgG sugar cores play a critical role in a number of IgG effector functions. In the present review, we describe the main characteristics o...
Main Authors: | Jean-Luc Teillaud, Riad Abès |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2010-01-01
|
Series: | Pharmaceuticals |
Subjects: | |
Online Access: | http://www.mdpi.com/1424-8247/3/1/146/ |
Similar Items
-
Fc-Glycosylation in Human IgG1 and IgG3 Is Similar for Both Total and Anti-Red-Blood Cell Anti-K Antibodies
by: Myrthe E. Sonneveld, et al.
Published: (2018-01-01) -
A Monosaccharide Residue Is Sufficient to Maintain Mouse and Human IgG Subclass Activity and Directs IgG Effector Functions to Cellular Fc Receptors
by: Daniela Kao, et al.
Published: (2015-12-01) -
The Ligands for Human IgG and Their Effector Functions
by: Steven W. de Taeye, et al.
Published: (2019-04-01) -
Regulation and Programming of Antibody Effector Function through IgG Glycosylation
by: Mahan, Alison Emilia
Published: (2014) -
IgG Fc Glycosylation Patterns of Preterm Infants Differ With Gestational Age
by: Nele Twisselmann, et al.
Published: (2019-01-01)